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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pleiotropic Genes Affecting Carcass Traits in Bos indicus (Nellore) Cattle Are Modulators of Growth

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Pereira, Anirene G. T. [1, 2] ; Utsunomiya, Yuri T. [3, 1] ; Milanesi, Marco [1, 4] ; Torrecilha, Rafaela B. P. [3, 1] ; Carmo, Adriana S. [3, 1] ; Neves, Haroldo H. R. [5] ; Carvalheiro, Roberto [6] ; Ajmone-Marsan, Paolo [7] ; Sonstegard, Tad S. [8] ; Solkner, Johann [9] ; Contreras-Castillo, Carmen J. [2] ; Garcia, Jose F. [3, 1, 4]
Total Authors: 12
[1] IAEA, Collaborating Ctr Anim Genom & Bioinformat, Aracatuba, SP - Brazil
[2] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, Dept Agroind Alimentos & Nutr, Piracicaba - Brazil
[3] UNESP Univ Estadual Paulista, Dept Med Vet Prevent & Reprod Anim, Fac Ciencias Agr & Vet, Jaboticabal, SP - Brazil
[4] UNESP Univ Estadual Paulista, Dept Apoio Prod & Saude Anim, Fac Med Vet & Aracatuba, Aracatuba, SP - Brazil
[5] GenSys Consultores Assoc, Porto Alegre, RS - Brazil
[6] UNESP Univ Estadual Paulista, Dept Zootecnia, Fac Ciencias Agr & Vet, Jaboticabal, SP - Brazil
[7] Univ Cattolica Sacro Cuore, Piacenza - Italy
[8] Recombinetics Inc, St Paul, MN - USA
[9] BOKU Univ Nat Resources & Life Sci, Dept Sustainable Agr Syst, Div Livestock Sci, Vienna - Austria
Total Affiliations: 9
Document type: Journal article
Source: PLoS One; v. 11, n. 7 JUL 13 2016.
Web of Science Citations: 5

Two complementary methods, namely Multi-Trait Meta-Analysis and Versatile Gene-Based Test for Genome-wide Association Studies (VEGAS), were used to identify putative pleiotropic genes affecting carcass traits in Bos indicus (Nellore) cattle. The genotypic data comprised over 777,000 single-nucleotide polymorphism markers scored in 995 bulls, and the phenotypic data included deregressed breeding values (dEBV) for weight measurements at birth, weaning and yearling, as well visual scores taken at weaning and yearling for carcass finishing precocity, conformation and muscling. Both analyses pointed to the pleomorphic adenoma gene 1 (PLAG1) as a major pleiotropic gene. VEGAS analysis revealed 224 additional candidates. From these, 57 participated, together with PLAG1, in a network involved in the modulation of the function and expression of IGF1 (insulin like growth factor 1), IGF2 (insulin like growth factor 2), GH1 (growth hormone 1), IGF1R (insulin like growth factor 1 receptor) and GHR (growth hormone receptor), suggesting that those pleiotropic genes operate as satellite regulators of the growth pathway. (AU)

FAPESP's process: 13/02552-0 - Genome association study in Nellore cattle for quantitative and qualitative characteristics of carcass and meat
Grantee:Anirene Galvão Tavares Pereira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/01095-8 - Use of next generation sequencing for the fine mapping of loci explaining variance in scrotal circumference in Nellore cattle
Grantee:Yuri Tani Utsunomiya
Support type: Scholarships in Brazil - Doctorate