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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Viral Inhibition Mechanism Mediated by Surface-Modified Silica Nanoparticles

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de Souza e Silva, Juliana Martins [1, 2, 3] ; Melo Hanchuk, Talita Diniz [4, 5, 6] ; Santos, Murilo Izidoro [1] ; Kobarg, Joerg [4, 5, 6] ; Bajgelman, Marcio Chaim [4] ; Cardoso, Mateus Borba [1]
Total Authors: 6
[1] Natl Ctr Res Energy & Mat, Brazilian Synchrotron Light Lab, BR-13083970 Campinas, SP - Brazil
[2] Tech Univ Munich, Phys Dept, Lehrstuhl Biomed Phys, D-85748 Garching - Germany
[3] Tech Univ Munich, Inst Med Tech, D-85748 Garching - Germany
[4] Natl Ctr Res Energy & Mat, Brazilian Biosci Natl Lab, BR-13083970 Campinas, SP - Brazil
[5] Univ Estadual Campinas, Fac Pharmaceut Sci, BR-13083862 Campinas, SP - Brazil
[6] Univ Estadual Campinas, Dept Biochem & Tissue Biol, Inst Biol, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: ACS APPLIED MATERIALS & INTERFACES; v. 8, n. 26, p. 16564-16572, JUL 6 2016.
Web of Science Citations: 14

Vaccines and therapies are not available for several diseases caused by viruses, thus viral infections result in morbidity and mortality of millions of people every year. Nanoparticles are considered to be potentially effective in inhibiting viral infections. However, critical issues related to their use include their toxicity and their mechanisms of antiviral action, which are not yet completely elucidated. To tackle these problems, we synthesized silica nanoparticles with distinct surface properties and evaluated their biocompatibility and antiviral efficacy. We show that nanoparticles exhibited no significant toxicity to mammalian cells, while declines up to 50% in the viral transduction ability of two distinct recombinant viruses were observed. We designed experiments to address the mechanism of antiviral action of our nanoparticles and found that their hydrophobic/hydrophilic characters play a crucial role. Our results reveal that the use of functionalized silica particles is a promising approach for controlling viral infection and offer promising strategies for viral control. (AU)

FAPESP's process: 14/22322-2 - Functionalization of silica nanoparticles: increasing biological interaction
Grantee:Mateus Borba Cardoso
Support type: Regular Research Grants
FAPESP's process: 12/05481-4 - Surface chemistry manipulation of silver-based nanocomposites: study of biocidal effect against enveloped virus
Grantee:Juliana Martins de Souza e Silva
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/12190-9 - Understanding the activity of functionalized nanoparticles against virus using coherent diffraction imaging
Grantee:Juliana Martins de Souza e Silva
Support type: Scholarships abroad - Research Internship - Post-doctor