Effect of Fluoride Concentration on Reduction of Enamel Demineralization According to the Cariogenic Challenge

Author(s)

Mayara dos Santos Noronha ^[1] ; Dayse Andrade Romão ^[2] ; Jaime Aparecido Cury ^[3] ; Cínthia Pereira Machado Tabchoury ^[4]

Affiliation

^[1] Universidade Estadual de Campinas - Brasil

^[2] Universidade Estadual de Campinas - Brasil

^[3] Universidade Estadual de Campinas - Brasil

^[4] Universidade Estadual de Campinas - Brasil

• Document type: Journal article
• Source: Brazilian Dental Journal; v. 27, n. 4, p. 393-398, 2016-08-00.

Abstract

Abstract Fluoride present in toothpaste at 1,100 µg/g is considered effective on caries control. However, under high cariogenic challenge due to increasing sugar exposure, higher fluoride concentration (5,000 µg/g) could be necessary to compensate the unbalance on caries process. This was tested in a pH-cycling regimen, which evaluated the effect of fluoride concentration relative to toothpaste on reduction of enamel demineralization under conditions of two levels of cariogenic challenge. Enamel slabs (n=20) were subjected to two pH-cycling regimens, simulating 8x and 16x/day sugar exposure and were treated with solutions containing: 0 (no fluoride), 275 or 1,250 µg F/mL, resulting in 6 treatment groups: 4-h/0-F; 8-h/0-F; 4-h/275-F; 8-h/275-F; 4-h/1,250-F and 8-h/1,250-F. The 275 and 1,250 µg F/mL concentrations simulate mouth salivary dilution when 1,100 and 5,000 µg/g toothpastes are used. Enamel demineralization was assessed by surface (%SHL) and cross-sectional hardness. Fluoride taken up by enamel was also evaluated. Data were analyzed by ANOVA one-way and Tukey's test. The treatment with 1,250 µg F/mL significantly reduced %SHL compared with 275 µg F/mL (p<0.05), irrespective the level of cariogenic challenge (4-h/1,250-F vs. 4-h/275-F and 8-h/1,250-F vs 8-h/275-F comparisons, respectively). These data were supported by fluoride concentration found in enamel. These findings suggest that higher fluoride concentrations could partly compensate the greater caries risk under higher cariogenic challenge due to increasing sugar exposure. (AU)

• FAPESP's process: 13/15251-9 - Validation of a pH-cycling model to estimate the potential of fluoridated products on the reduction of demineralization of enamel of deciduous teeth
• Grantee: Cinthia Pereira Machado Tabchoury
• Support Opportunities: Regular Research Grants