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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Stem cells derived from olfactory epithelium: therapeutic perspectives in veterinary medicine

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Author(s):
Rosane Mazzarella [1] ; Taismara K. Garnica [2] ; Kelly C.S. Roballo [3] ; Carlos E. Ambrósio [4]
Total Authors: 4
Affiliation:
[1] Universidade de São Paulo. Faculdade de Zootecnia e Engenharia de Alimentos. Departamento de Medicina Veterinária - Brasil
[2] Universidade de São Paulo. Faculdade de Zootecnia e Engenharia de Alimentos. Departamento de Medicina Veterinária - Brasil
[3] Universidade de São Paulo. Faculdade de Zootecnia e Engenharia de Alimentos. Departamento de Medicina Veterinária - Brasil
[4] Universidade de São Paulo. Faculdade de Zootecnia e Engenharia de Alimentos. Departamento de Medicina Veterinária - Brasil
Total Affiliations: 4
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 36, n. 8, p. 787-792, 2016-08-00.
Abstract

Abstract: The olfactory epithelium (OE) is a promising source of stem cells (OESC) for therapeutic use in veterinary and human medicine, especially in diseases correlated with the peripheral (spinal cord) and central (brain and brainstem) nervous system (CNS), because of its ability to differentiate into neurons, astrocytes and oligodendrocytes cells. In humans, OESC has been used primarily in therapeutic trials for degenerative diseases such as Alzheimer and Parkinson. In animals, the frequency of corresponding cases of chronic or acute neurodegenerative diseases is very low, because of the difficulty of a definitive diagnosis; thus, the focus of cell therapy research are mostly mechanical spinal cord injuries. Due to the lack of normalization and selection of the best methodologies for comparative studies, this review aims to analyze recent reports on the potential use of stem cells from the olfactory epithelium in cell therapies and to discuss the main challenges and future prospects in veterinary medicine. (AU)

FAPESP's process: 15/17897-9 - Exosomal communication in the stem cells transdifferentiation in co-culture with neuronal cells
Grantee:Kelly Cristine Santos Roballo
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)