Analysis of the Therapeutic potential of cells derived from the vomeronasal organ of rabbits New Zeland

• Grant number: 12/11560-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): October 01, 2012
• Effective date (End): May 29, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine
• Principal Investigator: Maria Angelica Miglino
• Grantee: Marcio Nogueira Rodrigues
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 13/07824-9 - Inflamatory response in spinal cord injury treated with VEGF and PDGF, BE.EP.DR

Abstract

The vomeronasal organ is located at the base of the nasal cavity, has tubular shape, is divided by the nasal septum and is part of the olfactory system. It emits chemical signals that detect pheromones and modulate social and reproductive behavior through their receptors that pick up stimuli quimiosensitivos. It is a distinctly quimiosensorial body and is well developed in mammals especially in rabbits. The vomeronasal organ has sensory cells to undergo neurogenesis throughout life, this body stem cells adjacent to the basal layer divide and migrate to replace sensory neurons, these stem cells can generate functional neurons throughout life and age of animal in particular. Thus, we think that this regenerative capacity may in future provide persistent hope in regenerative medicine and used as a source for cell therapy. Stem cells of the basal vomeronasal organ does not form distinct layers of cells, such as those that occur in the olfactory epithelium, they exist and are distributed not only at the margins, but across the epithelium of the organ. In this project we aim to isolate, characterize cells derived from the vomeronasal organ of New Zealand rabbits as well as test its therapeutic potential in the treatment of destructive lesions of the vomeronasal pathway. In addition, we also have the future in order to study about the reproductive behavior of these animals injured, animal with injury has been shown that the loss of this organ leads to behavioral disorders and sex of these animals

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARRETO, RODRIGO S. N.; DE OLIVEIRA, FRANCELIUSA DELYS; MATIAS, GUSTAVO DE SA SCHIAVO; RODRIGUES, MARCIO N.; CARVALHO, RAFAEL C.; FRANCIOLLI, ANDRE LUIS R.; FRATINI, PAULA; MIGLINO, MARIA ANGELICA. Rabbit Vomeronasal Organ-Derkered Cells lime Mesenchymal Profile and Neuronal Commitment. INTERNATIONAL JOURNAL OF MORPHOLOGY, v. 38, n. 5, p. 1463-1472, OCT 2020. (12/11560-4)

RODRIGO S. N BARRETO; FRANCELIUSA DELYS DE-OLIVEIRA; GUSTAVO DE SÁ SCHIAVO MATIAS; MARCIO N RODRIGUES; RAFAEL C CARVALHO; ANDRÉ LUIS R FRANCIOLLI; PAULA FRATINI; MARIA ANGELICA MIGLINO. Rabbit Vomeronasal Organ-Derivered Cells Have Mesenchymal Profile and Neuronal Commitment. INTERNATIONAL JOURNAL OF MORPHOLOGY, v. 38, n. 5, p. 1463-1472, 2020-10-00. (12/11560-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

RODRIGUES, Marcio Nogueira. Analysis of therapeutic potential of cells from vomeronasal organ of rabbits New Zealand. 2014. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.