| Full text | |
| Author(s): |
Bispo, Vanderson S.
;
de Arruda Campos, Ivan P.
;
Di Mascio, Paolo
;
Medeiros, Marisa H. G.
Total Authors: 4
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 6, JAN 19 2016. |
| Web of Science Citations: | 10 |
| Abstract | |
Aldehydes accumulate in inflammation, during myocardial infarction and have been associated with pain symptoms. One pathway of aldehyde detoxification is the conjugation with carnosine. A 3-methylpyridinium carnosine adduct from the reaction of carnosine and acrolein was characterized using extensive spectroscopic measurements. The adduct with urinary concentrations of 1.82 +/- 0.68 nmol/mg of creatinine is one of the most abundant acrolein metabolites in urine and opens promising therapeutic strategies for carnosine. (AU) | |
| FAPESP's process: | 12/12663-1 - Singlet molecular oxygen and peroxides in chemical biology |
| Grantee: | Paolo Di Mascio |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 11/10048-5 - Mapping adducts generated by endogenous and exogenous aldehydes: use as biomarkers of redox stress |
| Grantee: | Marisa Helena Gennari de Medeiros |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 13/07937-8 - Redoxome - Redox Processes in Biomedicine |
| Grantee: | Ohara Augusto |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |