| Full text | |
| Author(s): Show less - |
Gontijo, Talita B.
;
de Freitas, Rossimiriam P.
;
de Lima, Guilherme F.
;
de Rezende, Lucas C. D.
;
Pedrosa, Leandro F.
;
Silva, Thaissa L.
;
Goulart, Marilia O. F.
;
Cavalcanti, Bruno C.
;
Pessoa, Claudia
;
Bruno, Marina P.
;
Correa, Jose R.
;
Emery, Flavio S.
;
da Silva Junior, Eufranio N.
Total Authors: 13
|
| Document type: | Journal article |
| Source: | CHEMICAL COMMUNICATIONS; v. 52, n. 90, p. 13281-13284, 2016. |
| Web of Science Citations: | 14 |
| Abstract | |
For the first time, a fluorescent lapachone-based BODIPY was synthesised and characterised by NMR and mass spectrometry. Computational and electrochemical aspects, as well as cytotoxic activity and subcellular localisation, were studied. Confocal microscopy experiments indicated that the probe was a specific mitochondria-staining agent. These in-detail analyses were useful in understanding the cytotoxic effects and mechanism of action of this novel hybrid compound. This molecule constitutes a promising prototype owing to its potential biological activities and the new strategies aimed at mechanistic investigations in cells and in vivo, and opens up an interesting avenue of research. (AU) | |
| FAPESP's process: | 14/22451-7 - Sustained drug delivery systems targeting the epithelial tissue |
| Grantee: | Renata Fonseca Vianna Lopez |
| Support Opportunities: | Research Projects - Thematic Grants |