Abstract
The aim of this proposal is to establish a platform for the development of topical delivery systems that ensure the targeted and sustained release of drugs to the epithelial tissue that forms the skin and the cornea. The design of drug delivery systems for topical treatment should take into account the integrity of the epithelium where they will be applied, the layer of this epithelium in which the disease is inserted, the physicochemical characteristics of the substances to be administered and the rate that these substances must be released to have the intended action. Due to the complexity to correlate all these variables, the project is divided into 2 parts. In the first one, delivery systems will be developed for application in non-intact epithelia, aimed at treating chronic wounds. The current market lacks products that combine substances that are effectives in the various stages of the healing process, that release these substances in a programmed period and that protect the wounds against physical and microbiological damage. Thus, the first part of this project proposes the development of delivery systems for macromolecules in a step, using fibroin based delivery systems, and for small molecules, but associated in a same system, in other step. The second part of the project aims at the development of delivery systems for application in intact and keratinized epithelia, such as skin tumors, where it is necessary to extrapolate the keratinized barrier and carry large quantities of active substance, released during long periods, for layers of the epithelium that require treatment. In this part of the project, the influence of iontophoresis and ultrasound in the release rate of drugs dispersed in liquid crystalline systems will be explored for the first time. (AU)
Scientific publications
(20)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CUBAYACHI, CAMILA;
LEMOS, CAMILA NUNES;
PEREIRA, FRANCIELI;
DIAS, KARINA;
HERCULANO, RONDINELLI DONIZETTI;
DE FREITAS, OSVALDO;
LOPEZ, RENATA F. V.
Silk fibroin films stabilizes and releases bioactive insulin for the treatment of corneal wounds.
EUROPEAN POLYMER JOURNAL,
v. 118,
p. 502-513,
SEP 2019.
Web of Science Citations: 1.
CRUZ-CAZARIM, ESTAEL L. C.;
CAZARIM, MAURILIO S.;
OGUNJIMI, ABAYOMI T.;
PETRILLI, RAQUEL;
ROCHA, EDUARDO M.;
LOPEZ, V, RENATA F.
Prospective insulin-based ophthalmic delivery systems for the treatment of dry eye syndrome and corneal injuries.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,
v. 140,
p. 1-10,
JUL 2019.
Web of Science Citations: 0.
NOMINATO, LUIS FERNANDO;
DIAS, ANA CAROLINA;
DIAS, LARA CRISTINA;
FANTUCCI, MARINA ZILIO;
COSTA MENDES DA SILVA, LILIAN ESLAINE;
MURASHIMA, ADRIANA DE ANDRADE;
ROCHA, EDUARDO MELANI.
Prevention of Corneal Neovascularization by Adenovirus Encoding Human Vascular Endothelial Growth Factor Soluble Receptor (s-VEGFR1) in Lacrimal Gland.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,
v. 59,
n. 15,
p. 6036-6044,
DEC 2018.
Web of Science Citations: 1.
PETRILLI, RAQUEL;
ELOY, JOSIMAR O.;
SAGGIORO, FABIANO P.;
CHESCA, DEISE L.;
DE SOUZA, MARINA CLARO;
DIAS, MARCOS V. S.;
DASILVA, LUIS L. P.;
LEE, ROBERT J.;
LOPEZ, RENATA F. V.
Skin cancer treatment effectiveness is improved by iontophoresis of EGFR-targeted liposomes containing 5-FU compared with subcutaneous injection.
JOURNAL OF CONTROLLED RELEASE,
v. 283,
p. 151-162,
AUG 10 2018.
Web of Science Citations: 5.
LEMOS, CAMILA NUNES;
CUBAYACHI, CAMILA;
DIAS, KARINA;
MENDONCA, JACQUELINE NAKAU;
LOPES, NORBERTO PEPORINE;
JACOMETTI CARDOSO FURTADO, NIEGE ARACARI;
LOPEZ, V, RENATA F.
Iontophoresis-stimulated silk fibroin films as a peptide delivery system for wound healing.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,
v. 128,
p. 147-155,
JUL 2018.
Web of Science Citations: 4.
REZENDE, LUCAS C. D.;
MELO, SHAIANI M. G.;
BOODTS, STIJN;
VERBELEN, BRAM;
EMERY, FLAVIO S.;
DEHAEN, WIM.
Thiocyanation of 3-substituted and 3,5-disubstituted BODIPYs and its application for the synthesis of new fluorescent sensors.
DYES AND PIGMENTS,
v. 154,
p. 155-163,
JUL 2018.
Web of Science Citations: 7.
DO COUTO, RENE OLIVEIRA;
CUBAYACHI, CAMILA;
CALEFI, PAULO LINARES;
VIANNA LOPEZ, RENATA FONSECA;
PEDRAZZI, VINICIUS;
DE GAITANI, CRISTIANE MASETTO;
DE FREITAS, OSVALDO.
Combining amino amide salts in mucoadhesive films enhances needle-free buccal anesthesia in adults.
JOURNAL OF CONTROLLED RELEASE,
v. 266,
p. 205-215,
NOV 28 2017.
Web of Science Citations: 4.
GONTIJO, TALITA B.;
DE FREITAS, ROSSIMIRIAM P.;
EMERY, FLAVIO S.;
PEDROSA, LEANDRO F.;
VIEIRA NETO, JOSE B.;
CAVALCANTI, BRUNO C.;
PESSOA, CLAUDIA;
KING, AARON;
DE MOLINER, FABIO;
VENDRELL, MARC;
DA SILVA JUNIOR, EUFRNIO N.
On the synthesis of quinone-based BODIPY hybrids: New insights on antitumor activity and mechanism of action in cancer cells.
Bioorganic & Medicinal Chemistry Letters,
v. 27,
n. 18,
p. 4446-4456,
SEP 15 2017.
Web of Science Citations: 7.
BERNARDI, DANIELA S.;
BITENCOURT, CLAUDIA;
DA SILVEIRA, DENISE S. C.;
DA CRUZ, ESTAEL L. C. M.;
PEREIRA-DA-SILVA, MARCELO A.;
FACCIOLI, LUCIA HELENA;
LOPEZ, RENATA F. V.
Effective transcutaneous immunization using a combination of iontophoresis and nanoparticles.
Nanomedicine-Nanotechnology Biology and Medicine,
v. 12,
n. 8,
p. 2439-2448,
NOV 2016.
Web of Science Citations: 12.
GONTIJO, TALITA B.;
DE FREITAS, ROSSIMIRIAM P.;
DE LIMA, GUILHERME F.;
DE REZENDE, LUCAS C. D.;
PEDROSA, LEANDRO F.;
SILVA, THAISSA L.;
GOULART, MARILIA O. F.;
CAVALCANTI, BRUNO C.;
PESSOA, CLAUDIA;
BRUNO, MARINA P.;
CORREA, JOSE R.;
EMERY, FLAVIO S.;
DA SILVA JUNIOR, EUFRANIO N.
Novel fluorescent lapachone-based BODIPY: synthesis, computational and electrochemical aspects, and subcellular localisation of a potent antitumour hybrid quinone.
CHEMICAL COMMUNICATIONS,
v. 52,
n. 90,
p. 13281-13284,
2016.
Web of Science Citations: 14.