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Sustained drug delivery systems targeting the epithelial tissue

Abstract

The aim of this proposal is to establish a platform for the development of topical delivery systems that ensure the targeted and sustained release of drugs to the epithelial tissue that forms the skin and the cornea. The design of drug delivery systems for topical treatment should take into account the integrity of the epithelium where they will be applied, the layer of this epithelium in which the disease is inserted, the physicochemical characteristics of the substances to be administered and the rate that these substances must be released to have the intended action. Due to the complexity to correlate all these variables, the project is divided into 2 parts. In the first one, delivery systems will be developed for application in non-intact epithelia, aimed at treating chronic wounds. The current market lacks products that combine substances that are effectives in the various stages of the healing process, that release these substances in a programmed period and that protect the wounds against physical and microbiological damage. Thus, the first part of this project proposes the development of delivery systems for macromolecules in a step, using fibroin based delivery systems, and for small molecules, but associated in a same system, in other step. The second part of the project aims at the development of delivery systems for application in intact and keratinized epithelia, such as skin tumors, where it is necessary to extrapolate the keratinized barrier and carry large quantities of active substance, released during long periods, for layers of the epithelium that require treatment. In this part of the project, the influence of iontophoresis and ultrasound in the release rate of drugs dispersed in liquid crystalline systems will be explored for the first time. (AU)

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Scientific publications (51)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GONTIJO, TALITA B.; DE FREITAS, ROSSIMIRIAM P.; DE LIMA, GUILHERME F.; DE REZENDE, LUCAS C. D.; PEDROSA, LEANDRO F.; SILVA, THAISSA L.; GOULART, MARILIA O. F.; CAVALCANTI, BRUNO C.; PESSOA, CLAUDIA; BRUNO, MARINA P.; et al. Novel fluorescent lapachone-based BODIPY: synthesis, computational and electrochemical aspects, and subcellular localisation of a potent antitumour hybrid quinone. CHEMICAL COMMUNICATIONS, v. 52, n. 90, p. 13281-13284, . (14/22451-7)
PETRILLI, RAQUEL; VIANNA LOPEZ, RENATA FONSECA. Physical methods for topical skin drug delivery: concepts and applications. Brazilian Journal of Pharmaceutical Sciences, v. 54, n. SI, . (17/05930-7, 14/22451-7)
CRUZ-CAZARIM, ESTAEL L. C.; CAZARIM, MAURILIO S.; OGUNJIMI, ABAYOMI T.; PETRILLI, RAQUEL; ROCHA, EDUARDO M.; LOPEZ, V, RENATA F.. Prospective insulin-based ophthalmic delivery systems for the treatment of dry eye syndrome and corneal injuries. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 140, p. 1-10, . (16/03584-1, 14/22451-7)
OGUNJIMI, ABAYOMI TOLULOPE; CHAHUD, FERNANDO; LOPEZ, RENATA F. V.. Isotretinoin-Delonix polymeric nanoparticles: Potentials for skin follicular targeting in acne treatment. International Journal of Pharmaceutics, v. 610, . (14/22451-7, 14/50928-2)
JACQUELINE FERREIRA FAUSTINO BARROS; ARIANE MIRELA SARANZO SANT'ANA; LARA CRISTINA DIAS; ADRIANA DE ANDRADE BATISTA MURASHIMA; LILIAN ESLAINE COSTA MENDES DA SILVA; MARINA ZILIO FANTUCCI; EDUARDO MELANI ROCHA. Comparação dos efeitos da denervação da córnea e da glândula lacrimal na unidade funcional lacrimal de ratos. Arquivos Brasileiros de Oftalmologia, v. 85, n. 1, p. 59-67, . (14/22451-7, 14/23211-0)
LEIDIANE ADRIANO; ETIENE LORRIANE DE SOUZA PERSONA; ISVANDER GUSTAVO DE SOUZA PERSONA; REGINA CELIA NUCCI PONTELLI; EDUARDO M. ROCHA. Correlation between the presumed pterygium with dry eye and with systemic and ocular risk factors. Arquivos Brasileiros de Oftalmologia, n. ahead, p. -, . (14/22451-7)
DE OLIVEIRA, FABIOLA REIS; MOTTA, ANA CAROLINA F.; MODULO, CAROLINA MARIA; GARCIA, DENNY MARCOS; CHIORINI, JOHN A.; LOUZADA-JUNIOR, PAULO; ROCHA, EDUARDO MELANI. Clinical and laboratory evaluation of sicca complaints: distinctive aspects of primary, secondary and non-Sjogren syndrome. ADVANCES IN RHEUMATOLOGY, v. 62, n. 1, p. 13-pg., . (15/07249-0, 14/22451-7)
MARTIN, BIANCA APARECIDA; LEMOS, CAMILA NUNES; DALMOLIN, LUCIANA FACCO; ARRUDA, CAROLINE; BRAIT, IRIS SPERCHI CAMILO; CAZARIM, MAURILIO DE SOUZA; DA CRUZ-CAZARIM, ESTAEL LUZIA COELHO; BUENO, PAULA CAROLINA PIRES; JUNIOR, MAURILIO POLIZELLO; PEREIRA, LEONARDO REGIS LEIRA; et al. A New Approach to Atopic Dermatitis Control with Low-Concentration Propolis-Loaded Cold Cream. PHARMACEUTICS, v. 13, n. 9, . (17/19193-4, 14/22451-7)
AMANDA PIRES BARBOSA; FABÍOLA REIS DE OLIVEIRA; FLAVIO JAIME DA ROCHA; VALDAIR FRANCISCO MUGLIA; EDUARDO MELANI ROCHA. Lacrimal gland atrophy and dry eye related to isotretinoin, androgen, and prolactin: differential diagnosis for Sjogren's syndrome. Arquivos Brasileiros de Oftalmologia, v. 84, n. 1, p. 78-82, . (14/23211-0, 14/22451-7)
LEIDIANE ADRIANO; ETIENE LORRIANE DE SOUZA PERSONA; ISVANDER GUSTAVO DE SOUZA PERSONA; REGINA CELIA NUCCI PONTELLI; EDUARDO M. ROCHA. Correlação entre o pterígio presumível com olho seco e com fatores de risco sistêmicos e oculares. Arquivos Brasileiros de Oftalmologia, v. 85, n. 2, p. 136-143, . (14/22451-7)
BARBOSA, AMANDA PIRES; ALVES, MONICA; FORTES FURTADO, JOAO MARCELLO; ADRIANO, LEIDIANE; NOMINATO, LUIS FERNANDO; DIAS, LARA CRISTINA; FANTUCCI, MARINA ZILIO; BATISTA MURASHIMA, ADRIANA DE ANDRADE; ROCHA, EDUARDO MELANI. Corneal blindness in Plato's cave: the acting forces to prevent and revert corneal opacity. Part I: epidemiology and new physiopathological concepts. Arquivos Brasileiros de Oftalmologia, v. 83, n. 5, p. 437-446, . (14/22451-7)
GIL DE MELO, SHAIANI MARIA; DIAS DE REZENDE, LUCAS CUNHA; PETRILLI, RAQUEL; VIANNA LOPEZ, RENATA FONSECA; GOULART, MARILIA O. F.; EMERY, FLAVIO DA SILVA. Nitrosation of BODIPY dyes and their applications in the development of thiol sensors. DYES AND PIGMENTS, v. 173, . (13/50677-7, 14/18973-8, 11/23342-9, 14/22451-7, 17/21146-4)
DIAS, LARA CRISTINA; ZHENG, CHANGYU; MURASHIMA, ADRIANA DE ANDRADE BATISTA; DIAS, ANA CAROLINA; FANTUCCI, MARINA ZILIO; NOMINATO, LUIZ FERNANDO; DA SILVA, LILIAN ESLAINE COSTA MENDES; ROCHA, EDUARDO MELANI. Lacrimal Gland as a Target Organ for Adenovirus Gene Therapy Encoding Erythropoietin for Dry Eye Induced by Benzalkonium Chloride. CURRENT EYE RESEARCH, . (14/22451-7)
MARTINS, YUGO ARAUJO; GONCALVES, TALITA MOTA; LOPEZ, RENATA F. V.. HPLC methods for choloroquine determination in biological samples and pharmaceutical products. DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, v. 29, n. 1, . (14/22451-7)
LEMOS, CAMILA NUNES; DA SILVA, LILIAN ESLAINE COSTA MENDES; FAUSTINO, JACQUELINE FERREIRA; FANTUCCI, MARINA ZILIO; MURASHIMA, ADRIANA DE ANDRADE BATISTA; ADRIANO, LEIDIANE; ALVES, MONICA; ROCHA, EDUARDO MELANI. Oxidative Stress in the Protection and Injury of the Lacrimal Gland and the Ocular Surface: are There Perspectives for Therapeutics?. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 10, p. 18-pg., . (14/22451-7)
ANTUNES-FOSCHINI, ROSALIA; ADRIANO, LEIDIANE; BATISTA MURASHIMA, ADRIANA DE ANDRADE; BARBOSA, AMANDA PIRES; NOMINATO, LUIS FERNANDO; DIAS, LARA CRISTINA; FANTUCCI, MARINA ZILIO; GARCIA, DENNY MARCOS; ALVES, MONICA; ROCHA, EDUARDO MELANI. Limitations and advances in new treatments and future perspectives of corneal blindness. Arquivos Brasileiros de Oftalmologia, v. 84, n. 3, p. 15-pg., . (14/22451-7)
PEREIRA OLIVEIRA, CYNTHIA NARA; NANI LEITE, MARCEL; DE PAULA, NATALIA APARECIDA; ARAUJO MARTINS, YUGO; FIGUEIREDO, SONIA APARECIDA; CIPRIANI FRADE, MARCO ANDREY; LOPEZ, RENATA FONSECA VIANNA. Nanoemulsions Based on Sunflower and Rosehip Oils: The Impact of Natural and Synthetic Stabilizers on Skin Penetration and an Ex Vivo Wound Healing Model. PHARMACEUTICS, v. 15, n. 3, p. 24-pg., . (14/22451-7, 16/16437-7, 14/50928-2)
VIOLA, SOFIA GEROTTO; DALMOLIN, LUCIANA FACCO; MUNOZ, JANETTE BETZABETH VILLARRUEL; MARTINS, YUGO ARAUJO; RE, ANA CAROLINA DOS SANTOS; AIRES, CAROLINA PATRICIA; LOPEZ, RENATA FONSECA VIANNA. Investigation of the antimicrobial effect of anodic iontophoresis on Gram-positive and Gram-negative bacteria for skin infections treatment. BIOELECTROCHEMISTRY, v. 151, p. 10-pg., . (14/22451-7, 19/25710-7)
PETRILLI, RAQUEL; VIANNA LOPEZ, RENATA FONSECA. Physical methods for topical skin drug delivery: concepts and applications. Brazilian Journal of Pharmaceutical Sciences, v. 54, p. 19-pg., . (14/22451-7, 17/05930-7)
GONTIJO, TALITA B.; DE FREITAS, ROSSIMIRIAM P.; EMERY, FLAVIO S.; PEDROSA, LEANDRO F.; VIEIRA NETO, JOSE B.; CAVALCANTI, BRUNO C.; PESSOA, CLAUDIA; KING, AARON; DE MOLINER, FABIO; VENDRELL, MARC; et al. On the synthesis of quinone-based BODIPY hybrids: New insights on antitumor activity and mechanism of action in cancer cells. Bioorganic & Medicinal Chemistry Letters, v. 27, n. 18, p. 4446-4456, . (14/22451-7)
LEMOS, CAMILA NUNES; CUBAYACHI, CAMILA; DIAS, KARINA; MENDONCA, JACQUELINE NAKAU; LOPES, NORBERTO PEPORINE; JACOMETTI CARDOSO FURTADO, NIEGE ARACARI; LOPEZ, V, RENATA F.. Iontophoresis-stimulated silk fibroin films as a peptide delivery system for wound healing. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 128, p. 147-155, . (14/22451-7)
PETRILLI, RAQUEL; ELOY, JOSIMAR O.; SAGGIORO, FABIANO P.; CHESCA, DEISE L.; DE SOUZA, MARINA CLARO; DIAS, MARCOS V. S.; DASILVA, LUIS L. P.; LEE, ROBERT J.; LOPEZ, RENATA F. V.. Skin cancer treatment effectiveness is improved by iontophoresis of EGFR-targeted liposomes containing 5-FU compared with subcutaneous injection. JOURNAL OF CONTROLLED RELEASE, v. 283, p. 151-162, . (14/22451-7, 13/15134-2, 12/23764-3)
NOMINATO, LUIS FERNANDO; DIAS, ANA CAROLINA; DIAS, LARA CRISTINA; FANTUCCI, MARINA ZILIO; COSTA MENDES DA SILVA, LILIAN ESLAINE; MURASHIMA, ADRIANA DE ANDRADE; ROCHA, EDUARDO MELANI. Prevention of Corneal Neovascularization by Adenovirus Encoding Human Vascular Endothelial Growth Factor Soluble Receptor (s-VEGFR1) in Lacrimal Gland. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 59, n. 15, p. 6036-6044, . (14/22451-7)
AMANDA PIRES BARBOSA; MONICA ALVES; JOÃO MARCELLO FORTES FURTADO; LEIDIANE ADRIANO; LUIS FERNANDO NOMINATO; LARA CRISTINA DIAS; MARINA ZILIO FANTUCCI; ADRIANA DE ANDRADE BATISTA MURASHIMA; EDUARDO MELANI ROCHA. A cegueira corneal na caverna de Platão: as forças para prevenir e reverter a opacidade da córnea. Parte I: epidemiologia e novos conceitos na fisiopatologia. Arquivos Brasileiros de Oftalmologia, v. 83, n. 5, p. 437-446, . (14/22451-7)
OGUNJIMI, ABAYOMI T.; MELO, SHAIANI M. G.; VARGAS-RECHIA, CAREM G.; EMERY, FLAVIO S.; LOPEZ, RENATA F. V.. Hydrophilic polymeric nanoparticles prepared from Delonix galactomannan with low cytotoxicity for ocular drug delivery. Carbohydrate Polymers, v. 157, p. 1065-1075, . (14/22451-7)
REZENDE, LUCAS C. D.; MELO, SHAIANI M. G.; BOODTS, STIJN; VERBELEN, BRAM; EMERY, FLAVIO S.; DEHAEN, WIM. Thiocyanation of 3-substituted and 3,5-disubstituted BODIPYs and its application for the synthesis of new fluorescent sensors. DYES AND PIGMENTS, v. 154, p. 155-163, . (14/18973-8, 11/23342-9, 14/22451-7)
BERNARDI, DANIELA S.; BITENCOURT, CLAUDIA; DA SILVEIRA, DENISE S. C.; DA CRUZ, ESTAEL L. C. M.; PEREIRA-DA-SILVA, MARCELO A.; FACCIOLI, LUCIA HELENA; LOPEZ, RENATA F. V.. Effective transcutaneous immunization using a combination of iontophoresis and nanoparticles. Nanomedicine-Nanotechnology Biology and Medicine, v. 12, n. 8, p. 2439-2448, . (12/05177-3, 14/07125-6, 11/13307-1, 14/22451-7)
LEMOS, CAMILA NUNES; DE SOUZA, JOEL GONCALVES; SIMAO, PATRICIA SPER; VIANNA LOPEZ, RENATA FONSECA. Iontophoresis Improved Growth Reduction of Invasive Squamous Cell Carcinoma in Topical Photodynamic Therapy. PLoS One, v. 11, n. 1, . (11/21411-3, 14/22451-7)
DE SANTANA, DANIELLE C. A. S.; DIAS, KARINA; SOUZA, JOEL G.; OGUNJIMI, ABAYOMI T.; SOUZA, MARINA C.; SILVA, ROBERTO S.; LOPEZ, RENATA F. V.. NO Exchange for a Water Molecule Favorably Changes Iontophoretic Release of Ruthenium Complexes to the Skin. Molecules, v. 22, n. 1, . (14/22451-7)
PEREIRA, TATIANA APARECIDA; RAMOS, DANIELLE NISHIDA; LOPEZ, RENATA F. V.. Hydrogel increases localized transport regions and skin permeability during low frequency ultrasound treatment. SCIENTIFIC REPORTS, v. 7, . (10/20794-3, 14/22451-7, 11/06202-9)
GARCIA, DENNY MARCOS; DE OLIVEIRA, FABIOLA REIS; MODULO, CAROLINA MARIA; FAUSTINO, JACQUELINE; BARBOSA, AMANDA PIRES; ALVES, MONICA; ROCHA, EDUARDO MELANI. Is Sjogren's syndrome dry eye similar to dry eye caused by other etiologies? Discriminating different diseases by dry eye tests. PLoS One, v. 13, n. 12, . (14/23211-0, 14/22451-7)
PETRILLO, R.; ELOY, J. O.; PASCHOAL, J. A. R.; LOPEZ, V, R. F.. Quantification of 5-FU in skin samples for the development of new delivery systems for topical cancer treatment. Pharmazie, v. 73, n. 3, p. 133-138, . (14/22451-7, 13/15134-2, 12/23764-3)
FABIO, GABRIELLA BOVO; MARTIN, BIANCA APARECIDA; DALMOLIN, LUCIANA FACCO; LOPEZ, RENATA FONSECA VIANNA. Antimicrobial photodynamic therapy and the advances impacted by the association with nanoparticles. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 80, p. 13-pg., . (14/22451-7, 14/50928-2)
MO, YING-QIAN; NAKAMURA, HIROYUKI; TANAKA, TSUTOMU; ODANI, TOSHIO; PEREZ, PAOLA; JI, YOUNGMI; FRENCH, BENJAMIN N.; PRANZATELLI, THOMAS J. F.; MICHAEL, DREW G.; YIN, HONGEN; et al. Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjogren's syndrome. Journal of Clinical Investigation, v. 132, n. 6, p. 15-pg., . (14/22451-7, 14/23211-0)
DO COUTO, RENE OLIVEIRA; CUBAYACHI, CAMILA; DUARTE, MAIRA PERES FERREIRA; LOPEZ, RENATA FONSECA VIANNA; PEDRAZZI, VINICIUS; GAITANI, CRISTIANE MASETTO DE; FREITAS, OSVALDO DE. Towards the advance of a novel iontophoretic patch for needle-free buccal anesthesia. Materials Science & Engineering C-Materials for Biological Applications, v. 122, . (12/05644-0, 14/22451-7, 13/12174-3)
SHIKIDA, DANIELLE NISHIDA RAMOS; DALMOLIN, LUCIANA FACCO; FUMAGALLI, FERNANDO; EMERY, FLAVIO DA SILVA; LOPEZ, V, RENATA F.. Arginine-conjugated chitosan nanoparticles for topical arginine release in wounds. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 61, . (14/50928-2, 14/22451-7)
CAMPOS, PATRICIA MAZUREKI; PETRILLI, RAQUEL; LOPEZ, V, RENATA F.. The prominence of the dosage form design to treat ocular diseases. International Journal of Pharmaceutics, v. 586, . (17/05930-7, 14/50928-2, 14/22451-7)
SILVA FAVACHO, HUGO ALEXANDRE; DO COUTO, RENE OLIVEIRA; FERREIRA DUARTE, MAIRA PERES; GAROFO PEIXOTO, MARIA PAULA; VIANNA LOPEZ, RENATA FONSECA; PEDRAZZI, VINICIUS; DE GAITANI, CRISTIANE MASETTO; DE FREITAS, OSVALDO. Synergy between surfactants and mucoadhesive polymers enhances the transbuccal permeation of local anesthetics from freeze-dried tablets. Materials Science & Engineering C-Materials for Biological Applications, v. 108, . (12/05644-0, 12/06167-1, 12/07251-6, 13/12174-3, 14/22451-7)
DIAS, LARA CRISTINA; ZHENG, CHANGYU; MURASHIMA, ADRIANA DE ANDRADE BATISTA; DIAS, ANA CAROLINA; FANTUCCI, MARINA ZILIO; NOMINATO, LUIZ FERNANDO; DA SILVA, LILIAN ESLAINE COSTA MENDES; ROCHA, EDUARDO MELANI. Lacrimal Gland as a Target Organ for Adenovirus Gene Therapy Encoding Erythropoietin for Dry Eye Induced by Benzalkonium Chloride. CURRENT EYE RESEARCH, v. 46, n. 9, p. 1314-1319, . (14/22451-7)
MARTINS, YUGO ARAUJO; PAVAN, THEO ZEFERINO; LOPEZ, RENATA FONSECA VIANNA. Sonodynamic therapy: Ultrasound parameters and in vitro experimental configurations. International Journal of Pharmaceutics, v. 610, . (17/17442-7, 14/22451-7)
ANTUNES-FOSCHINI, ROSALIA; ADRIANO, LEIDIANE; BATISTA MURASHIMA, ADRIANA DE ANDRADE; BARBOSA, AMANDA PIRES; NOMINATO, LUIS FERNANDO; DIAS, LARA CRISTINA; FANTUCCI, MARINA ZILIO; GARCIA, DENNY MARCOS; ALVES, MONICA; ROCHA, EDUARDO MELANI. Limitações e avanços em novos tratamentos e perspectivas futuras na cegueira corneal. Arquivos Brasileiros de Oftalmologia, v. 84, n. 3, p. 282-296, . (14/22451-7)
MARTINS, YUGO A.; FONSECA, V, MARIA J.; PAVAN, THEO Z.; LOPEZ, V, RENATA F.. Bifunctional Therapeutic Application of Low-Frequency Ultrasound Associated with Zinc Phthalocyanine-Loaded Micelles. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 15, p. 8075-8095, . (14/22451-7, 17/17442-7, 14/50928-2)
DO COUTO, RENE OLIVEIRA; CUBAYACHI, CAMILA; CALEFI, PAULO LINARES; VIANNA LOPEZ, RENATA FONSECA; PEDRAZZI, VINICIUS; DE GAITANI, CRISTIANE MASETTO; DE FREITAS, OSVALDO. Combining amino amide salts in mucoadhesive films enhances needle-free buccal anesthesia in adults. JOURNAL OF CONTROLLED RELEASE, v. 266, p. 205-215, . (12/07251-6, 12/05644-0, 13/12174-3, 14/22451-7, 12/06167-1)
ADAMI, LARISSE EDUARDO; DE FREITAS, OSVALDO; TOCCHINI DE FIGUEIREDO, FELLIPE AUGUSTO; FERREIRA, MAIRA PERES; MACEDO, ANA PAULA; DO COUTO, RENE OLIVEIRA; PEDRAZZI, VINICIUS. Needle-free anesthesia: clinical efficacy of a mucoadhesive patch for atraumatic anesthesia in dental procedures. Brazilian Oral Research, v. 35, . (14/22451-7)
PETRILLI, RAQUEL; ELOY, JOSIMAR O.; LOPEZ, RENATA F. V.; LEE, ROBERT J.. Cetuximab Immunoliposomes Enhance Delivery of 5-FU to Skin Squamous Carcinoma Cells. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, v. 17, n. 2, p. 301-308, . (13/15134-2, 12/23764-3, 14/22451-7)
DALMOLIN, LUCIANA FACCO; LOPEZ, V, RENATA F.. Nanoemulsion as a Platform for Iontophoretic Delivery of Lipophilic Drugs in Skin Tumors. PHARMACEUTICS, v. 10, n. 4, . (14/22451-7)
OLIVEIRA, CAROLINA G.; DALMOLIN, LUCIANA F.; SILVA, R. T. C.; LOPEZ, V, RENATA F.; MAIA, PEDRO I. S.; MORETO, JEFERSON A.. PLGA-nanoparticles loaded with a thiosemicarbazone derived palladium(ii) complex as a potential agent to new formulations for human ovarian carcinoma treatment. NEW JOURNAL OF CHEMISTRY, v. 44, n. 35, p. 14928-14935, . (14/22451-7)
CUBAYACHI, CAMILA; LEMOS, CAMILA NUNES; PEREIRA, FRANCIELI; DIAS, KARINA; HERCULANO, RONDINELLI DONIZETTI; DE FREITAS, OSVALDO; LOPEZ, RENATA F. V.. Silk fibroin films stabilizes and releases bioactive insulin for the treatment of corneal wounds. EUROPEAN POLYMER JOURNAL, v. 118, p. 502-513, . (14/22451-7, 14/19018-0)
GARCIA, DENNY MARCOS; ADRIANO, LEIDIANE; NUCCI PONTELLI, REGINA CELIA; ROCHA, EDUARDO M.. A decision tree approach in dry eye disease: short questionnaire versus signs and symptoms diagnosis based in a household epidemiologic study. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 61, n. 7, p. 3-pg., . (14/22451-7)
TANAKA, TSUTOMU; WARNER, BLAKE M.; ODANI, TOSHIO; JI, YOUNGMI; MO, YING-QIAN; NAKAMURA, HIROYUKI; JANG, SHYH-ING; YIN, HONGEN; MICHAEL, DREW G.; HIRATA, NORIYUKI; et al. LAMP3 induces apoptosis and autoantigen release in Sjogren's syndrome patients. SCIENTIFIC REPORTS, v. 10, n. 1, p. 17-pg., . (14/22451-7, 14/23211-0)
FAUSTINO-BARROS, JACQUELINE FERREIRA; SANT'ANA, ARIANE MIRELA SARANZO; DIAS, LARA CRISTINA; MURASHIMA, ADRIANA DE ANDRADE BATISTA; DA SILVA, LILIAN ESLAINE COSTA MENDES; FANTUCCI, MARINA ZILIO; GARCIA, DENNY MARCOS; ROCHA, EDUARDO MELANI. Distinct Inflammatory and Oxidative Effects of Diabetes Mellitus and Hypothyroidism in the Lacrimal Functional Unit. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 8, p. 11-pg., . (14/23211-0, 14/22451-7)

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