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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Novel fluorescent lapachone-based BODIPY: synthesis, computational and electrochemical aspects, and subcellular localisation of a potent antitumour hybrid quinone

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Gontijo, Talita B. ; de Freitas, Rossimiriam P. ; de Lima, Guilherme F. ; de Rezende, Lucas C. D. ; Pedrosa, Leandro F. ; Silva, Thaissa L. ; Goulart, Marilia O. F. ; Cavalcanti, Bruno C. ; Pessoa, Claudia ; Bruno, Marina P. ; Correa, Jose R. ; Emery, Flavio S. ; da Silva Junior, Eufranio N.
Total Authors: 13
Document type: Journal article
Source: CHEMICAL COMMUNICATIONS; v. 52, n. 90, p. 13281-13284, 2016.
Web of Science Citations: 14

For the first time, a fluorescent lapachone-based BODIPY was synthesised and characterised by NMR and mass spectrometry. Computational and electrochemical aspects, as well as cytotoxic activity and subcellular localisation, were studied. Confocal microscopy experiments indicated that the probe was a specific mitochondria-staining agent. These in-detail analyses were useful in understanding the cytotoxic effects and mechanism of action of this novel hybrid compound. This molecule constitutes a promising prototype owing to its potential biological activities and the new strategies aimed at mechanistic investigations in cells and in vivo, and opens up an interesting avenue of research. (AU)

FAPESP's process: 14/22451-7 - Sustained drug delivery systems targeting the epithelial tissue
Grantee:Renata Fonseca Vianna Lopez
Support type: Research Projects - Thematic Grants