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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Local antibiotic delivery in periodontitis: drug release and its effect on supragingival biofilms

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Re, A. C. S. ; Ferreira, M. P. ; Freitas, O. ; Aires, C. P.
Total Authors: 4
Document type: Journal article
Source: BIOFOULING; v. 32, n. 9, p. 1061-1066, 2016.
Web of Science Citations: 4

The effect of a drug-delivery system containing antibacterial metronidazole (MDZ) prescribed for periodontitis on supragingival biofilm was evaluated, and possible interference by this biofilm in the drug release profile was investigated. Streptococcus mutans biofilms were grown and exposed to a controlled-release formulation of MDZ or the same formulation without MDZ (vehicle control). Untreated biofilms were used as a negative control (NC). Biofilms and culture medium (containing detached cells) were collected 24, 48, 72, and 96 h after first exposure to treatments. The biomass of the MDZ group was lower than that of the NC group at all times. Although MDZ yielded low drug-release rates in the presence of the biofilm, it was sufficient for reducing viability for 24 h and affecting bacterial metabolism for 48 h. These results suggest that MDZ appears to destabilize supragingival biofilm. This biofilm may interfere with MDZ release from the formulation. (AU)

FAPESP's process: 12/15556-1 - Suitability and effect of a controlled drug release system in presence of patogenic biofilm
Grantee:Ana Carolina dos Santos Ré
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/15423-1 - Suitability and effect of a controlled drug release system in presence of patogenic biofilm
Grantee:Carolina Patrícia Aires
Support type: Regular Research Grants