Mitochondrial Quality Control in Cardiac Diseases

Author(s)

Campos, Juliane C. ; Bozi, Luiz H. M. ; Bechara, Luiz R. G. ; Lima, Vanessa M. ; Ferreira, Julio C. B.

• Document type: Review article
• Source: FRONTIERS IN PHYSIOLOGY; v. 7, OCT 21 2016.
• Web of Science Citations: 12

Abstract

Disruption of mitochondrial homeostasis is a hallmark of cardiac diseases. Therefore, maintenance of mitochondrial integrity through different surveillance mechanisms is critical for cardiomyocyte survival. In this review, we discuss the most recent findings on the central role of mitochondrial quality control processes including regulation of mitochondrial redox balance, aldehyde metabolism, proteostasis, dynamics, and clearance in cardiac diseases, highlighting their potential as therapeutic targets. (AU)

• FAPESP's process: 12/19379-7 - Role of ALDH2*2 mutation in heart failure: therapeutic potential of Alda-1
• Grantee: Vanessa Morais Lima
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 12/14416-1 - Protein quality control profile in skeletal muscle wasting: role of beta2- adrenergic receptor
• Grantee: Juliane Cruz Campos
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/20783-5 - Protein quality control in dysfunctional/atrophic skeletal muscle: role of b2-adrenoceptor
• Grantee: Julio Cesar Batista Ferreira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/05765-2 - Contribution of aldehyde dehydrogenase 2 to heart failure development
• Grantee: Julio Cesar Batista Ferreira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 16/01633-5 - BETA2-ADRENOCEPTOR ACTIVATION COUNTERACTS SKELETAL MUSCLE WEAKNESS/WASTING: ROLE OF AUTOPHAGY
• Grantee: Juliane Cruz Campos
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate