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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

First Report of the Globally Disseminated IncX4 Plasmid Carrying the mcr-1 Gene in a Colistin-Resistant Escherichia coli Sequence Type 101 Isolate from a Human Infection in Brazil

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Author(s):
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Fernandes, Miriam R. ; McCulloch, John A. ; Vianello, Marco A. ; Moura, Quezia ; Perez-Chaparro, Paula J. ; Esposito, Fernanda ; Sartori, Luciana ; Dropa, Milena ; Matte, Maria H. ; Lira, Debora P. A. ; Mamizuka, Elsa M. ; Lincopan, Nilton
Total Authors: 12
Document type: Journal article
Source: Antimicrobial Agents and Chemotherapy; v. 60, n. 10, p. 6415-6417, OCT 2016.
Web of Science Citations: 57
Abstract

A colistin-resistant Escherichia coli strain was recovered from a patient with a diabetic foot infection in Brazil. Whole-genome analysis revealed that the E. coli isolate belonged to the widespread sequence type (ST) 101 and harbored the mcr-1 gene on an IncX4 plasmid that was highly similar to mcr-1-bearing IncX4 plasmids that were recently identified in Enterobacteriaceae from food, animal, and human samples recovered on different continents. These results suggest that self-transmissible IncX4-type plasmids may represent promiscuous plasmids contributing to the intercontinental spread of the mcr-1 gene. (AU)

FAPESP's process: 13/12107-4 - Study of the heterogeneous resistance to vancomycin in Staphylococcus aureus by comparative single-cell genomics of subpopulations in a single isolate
Grantee:John Anthony McCulloch
Support Opportunities: Scholarships in Brazil - Post-Doctoral