Genomic, proteomic and metabolomic study of gastrointestinal tissue for patients w...
| Full text | |
| Author(s): |
Molin Netto, Barbara Dal
;
Earthman, Carrie P.
;
Bettini, Solange Cravo
;
Grotti Clemente, Ana Paula
;
Landi Masquio, Deborah Cristina
;
Farias, Gisele
;
Boritza, Katia
;
da Silva, Larissa Gabrielle
;
von der Heyde, Maria Emilia
;
Damaso, Ana Raimunda
Total Authors: 10
|
| Document type: | Journal article |
| Source: | EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY; v. 28, n. 9, p. 1050-1055, SEP 2016. |
| Web of Science Citations: | 4 |
| Abstract | |
Introduction Body weight varies depending on the prevailing direction of environmental pressures; however, physiological factors also play a significant role in the control of body weight. The aim of the present study was to assess the impact of Roux-en-Y gastric bypass (RYGB) on hormones and peptides involved in the control of energy balance and their possible implications in appetite/satiety. Methods The sample included 39 individuals with extreme obesity (37 women and two men) who underwent RYGB. Anthropometric and biochemical markers were collected before surgery and 6 months after RYGB. Results The BMI decreased from 44.3 +/- 6.4 to 31.7 +/- 5.7 kg/m(2) (P<0.001) at the sixth month. Percentage of excess weight lost was 63.2 +/- 25.0%. Leptin and glucose levels decreased significantly 6 months after RYGB (P<0.001). Interestingly, a significant correlation was confirmed between the anorexigenic gut hormone peptide YY (PYY) and the central anorexigenic mediator alpha-melanocyte-stimulating hormone after 6 months of RYGB (r=0.35, P=0.004). In contrast, PYY concentrations were correlated negatively with BMI (r=-0.34, P=0.002). Conclusion In the present investigation, it was found that there is a relationship between a-melanocyte-stimulating hormone and PYY concentrations, and it supports the role of the PYY to POMC signal in appetite regulation after RYGB. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved. (AU) | |
| FAPESP's process: | 13/04136-4 - Analysis of neuroendocrine regulation of balance energy and inflammatory factors in obese adults submitted to bariatric surgery |
| Grantee: | Ana Raimunda Dâmaso |
| Support type: | Regular Research Grants |