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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Short-term cross-sensitizion of need-free sugar intake by combining sodium depletion and hypertonic NaCl intake

Full text
Author(s):
Santos, Bruna M. ; de Andrade, Carina A. F. ; Menani, Jose V. ; De Luca, Jr., Laurival A.
Total Authors: 4
Document type: Journal article
Source: APPETITE; v. 107, p. 79-85, DEC 1 2016.
Web of Science Citations: 0
Abstract

History of sodium depletion cross-sensitizes the effects of drugs of abuse. The objective of the present study was to find out if history of sodium depletion also cross-sensitizes a natural reward such as sugar intake in the rat. Sodium depletion was induced by furosemide combined with removal of ambient sodium for 24 h; it was repeated seven days later. The depletion was immediately followed by 03 M NaCl intake in a sodium appetite test (active sodium repletion). Seven days after the last depletion, hydrated and fed (need-free) sucrose-naive animals were offered 10% sucrose in a first 2-h sucrose test. The sucrose test was repeated once a day in a series of five consecutive days. History of sodium depletion enhanced sucrose intake in the first and second tests; it had no effect from the third to fifth sucrose test. The effect on the initial sucrose intake tests disappeared if the rats did not ingest 0.3 M NaCl in the sodium appetite test. Prior experience with sucrose intake in need-free conditions had no effect on sodium appetite. History of intracellular dehydration transiently influenced sucrose intake in the first sucrose test. We found no evidence for thirst sensitization. We conclude that history of dehydration, particularly that resulting from sodium depletion, combined to active sodium repletion, produced short-term cross-sensitization of sucrose intake in sucrose-naive rats. The results suggest that the cross sensitization of sucrose intake related with acquisition of sugar as a novel nutrient rather than production of lasting effects on sugar rewarding properties. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 11/50770-1 - Neural mechanisms involved of hydroelectrolytic balance and cardiorespiratory control
Grantee:José Vanderlei Menani
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 11/23696-5 - Dehydration and sugar intake
Grantee:Bruna Maitan Santos
Support Opportunities: Scholarships in Brazil - Scientific Initiation