Methylation status of homeobox genes in common human cancers

Author(s)

Setubal Destro Rodrigues, Maria Fernanda ; Esteves, Carina Magalhaes ; Aquino Xavier, Flavia Calo ; Nunes, Fabio Daumas

• Document type: Review article
• Source: Genomics; v. 108, n. 5-6, p. 185-193, DEC 2016.
• Web of Science Citations: 9

Abstract

Approximately 300 homeobox loci were identified in the euchromatic regions of the human genome, of which 235 are probable functional genes and 65 are likely pseudogenes. Many of these genes play important roles in embryonic development and cell differentiation. Dysregulation of homeobox gene expression is a frequent occurrence in cancer. Accumulating evidence suggests that as genetics disorders, epigenetic modifications alter the expression of oncogenes and tumor suppressor genes driving tumorigenesis and perhaps play a more central role in the evolution and progression of this disease. Here, we described the current knowledge regarding homeobox gene DNA methylation in human cancer and describe its relevance in the diagnosis, therapeutic response and prognosis of different types of human cancers. (C) 2016 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 10/08720-4 - Genetic, epigenetic and functional analysis of homeobox genes in oral squamous cell carcinoma
• Grantee: Fabio Daumas Nunes
• Support Opportunities: Regular Research Grants
• FAPESP's process: 08/06223-3 - Microarray expression profile of oral squamous cell carcinoma cell lines overexpressing HOXD11.
• Grantee: Fabio Daumas Nunes
• Support Opportunities: Regular Research Grants