MRZH reaction increases sensitivity for intrathecal IgG synthesis in IgG Oligoclonal band negative Multiple Sclerosis patients

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Dias-Carneiro, Rafael P. C. ; von Glehn, Felipe ; Moraes, Adriel S. ; Boldrini, Vinicius O. ; Damasceno, Alfredo ; Andrade, Marilia D. ; Lima, Alliny C. D. ; Casanova, Cristiane S. ; Tilbery, Charles P. ; Damasceno, Benito P. ; dos Santos, Leonilda M. B. ; Brandao, Carlos O.

• Document type: Journal article
• Source: Journal of Neuroimmunology; v. 300, p. 30-35, NOV 15 2016.
• Web of Science Citations: 2

Abstract

Given the low detection rates of CSF IgG-Oligoclonal bands (IgG-OCB) in non-European Multiple Sclerosis (MS) patients and higher specificity of the MRZH-reaction, we evaluated whether associating MRZH-reaction to CSF IgG-OCB detection improved investigation of suspected MS. Paired CSF and sera were analyzed for IgG-OCB and polyspecific viral antibodies. IgG-OCB were detected in 72% of MS patients and an MRZH-reaction in 67%. Combining lgG-OCB and MRZH raised detection of IgG abnormalities to 97% of studied MS patients. Detection of lgG-OCB and/or >= MRZH antibodies showed sensitivity of 88% and specificity of 92% for MS, versus 72% and 96% for IgG-OCB alone. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 12/04565-0 - Immunoregulatory function of HLA-G molecules in multiple sclerosis and experimental autoimmune encephalomyelitis
• Grantee: Leonilda Maria Barbosa dos Santos
• Support Opportunities: Regular Research Grants