Anti-Immune Strategies of Pathogenic Fungi

Author(s)

Marcos, Caroline M. ; de Oliveira, Haroldo C. ; Antunes de Melo, Wanessa de Cassia M. ; da Silva, Julhiany de Fatima ; Assato, Patricia A. ; Scorzoni, Liliana ; Rossi, Suelen A. ; de Paula e Silva, Ana C. A. ; Mendes-Giannini, Maria J. S. ; Fusco-Almeida, Ana M.

• Document type: Review article
• Source: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY; v. 6, NOV 15 2016.
• Web of Science Citations: 15

Abstract

Pathogenic fungi have developed many strategies to evade the host immune system. Multiple escape mechanisms appear to function together to inhibit attack by the various stages of both the adaptive and the innate immune response. Thus, after entering the host, such pathogens fight to overcome the immune system to allow their survival, colonization and spread to different sites of infection. Consequently, the establishment of a successful infectious process is closely related to the ability of the pathogen to modulate attack by the immune system. Most strategies employed to subvert or exploit the immune system are shared among different species of fungi. In this review, we summarize the main strategies employed for immune evasion by some of the major pathogenic fungi. (AU)

• FAPESP's process: 15/14023-8 - Use of peptides with anti-adhesive activity in Paracoccidoides spp. in the treatment and prophylaxis of the paracoccidioidomycosis
• Grantee: Haroldo Cesar de Oliveira
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 15/03700-9 - Alternative animal as a model to study Paracoccidioides- host interaction: virulence, efficacy and toxicology of antifungal compounds and new preventive treatments
• Grantee: Maria José Soares Mendes Giannini
• Support type: Regular Research Grants
• FAPESP's process: 13/10917-9 - Alternative animal models: Virulence of different phylogenetic species of Paracoccidioides and effect of the 30kDa 43kDa protein and their antibodies
• Grantee: Liliana Scorzoni
• Support type: Scholarships in Brazil - Post-Doctorate