Presence of Vaccine-Derived Newcastle Disease Viruses in Wild Birds

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Ayala, Andrea J. ; Dimitrov, Kiril M. ; Becker, Cassidy R. ; Goraichuk, Iryna V. ; Arns, Clarice W. ; Bolotin, Vitaly I. ; Ferreira, Helena L. ; Gerilovych, Anton P. ; Goujgoulova, Gabriela V. ; Martini, Matheus C. ; Muzyka, Denys V. ; Orsi, Maria A. ; Scagion, Guilherme P. ; Silva, Renata K. ; Solodiankin, Olexii S. ; Stegniy, Boris T. ; Miller, Patti J. ; Afonso, Claudio L.

• Document type: Journal article
• Source: PLoS One; v. 11, n. 9 SEP 14 2016.
• Web of Science Citations: 20

Abstract

Our study demonstrates the repeated isolation of vaccine-derived Newcastle disease viruses from different species of wild birds across four continents from 1997 through 2014. The data indicate that at least 17 species from ten avian orders occupying different habitats excrete vaccine-derived Newcastle disease viruses. The most frequently reported isolates were detected among individuals in the order Columbiformes (n = 23), followed in frequency by the order Anseriformes (n = 13). Samples were isolated from both free-ranging (n = 47) and wild birds kept in captivity (n = 7). The number of recovered vaccine-derived viruses corresponded with the most widely utilized vaccines, LaSota (n = 28) and Hitchner B1 (n = 19). Other detected vaccine-derived viruses resembled the PHY-LMV2 and V4 vaccines, with five and two cases, respectively. These results and the ubiquitous and synanthropic nature of wild pigeons highlight their potential role as indicator species for the presence of Newcastle disease virus of low virulence in the environment. The reverse spillover of live agents from domestic animals to wildlife as a result of the expansion of livestock industries employing massive amounts of live virus vaccines represent an underappreciated and poorly studied effect of human activity on wildlife. (AU)

• FAPESP's process: 15/11510-5 - Disclosing the host-pathogen and Pathogen-Pathogen interactions using metagenomics and high throughput sequencing approaches
• Grantee: Helena Lage Ferreira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/02059-2 - Serological, molecular detection, and characterization of avian paramyxovirus type-1 (class I and class II) in wild birds
• Grantee: Guilherme Pereira Scagion
• Support Opportunities: Scholarships in Brazil - Master