Development of polysaccharide-based membranes incorporating the bioactive compound aloin

Author(s)

Krause Bierhalz, Andrea Cristiane ; Lopes, Selma Aparecida ; Resende Pires, Ana Luiza ; Moraes, Angela Maria

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS; v. 66, n. 4, p. 193-202, 2017.
• Web of Science Citations: 4

Abstract

Chitosan-alginate (CA) and chitosan-xanthan (CX) membranes containing aloin were developed for use as wound dressings. The effects of aloin-to-biopolymer ratio on membranes morphology, aspect, liquid uptake, mass loss, mechanical properties, thermal behavior, aloin incorporation efficiency, and release kinetics were analyzed. CA membranes showed higher stability in liquid media and greater elongation at break. CX membranes had more homogeneous microstructure and slightly higher tensile strength. The opacity and color intensity of both formulations increased with aloin incorporation. Maximum aloin incorporation efficiencies were 56.0% and 79.5% in CA and CX membranes, respectively, and slower aloin release was observed for CA membranes. {[}GRAPHICS] . (AU)

• FAPESP's process: 13/23653-0 - DEVELOPMENT OF ALGINATE AND CHITOSAN MEMBRANES REINFORCED WITH FIBERS AND CONTAINING GROWTH FACTOR FOR TISSUE ENGINEERING APPLICATIONS
• Grantee: Andrea Cristiane Krause Bierhalz
• Support Opportunities: Scholarships in Brazil - Post-Doctoral