Brazilian-Portuguese translation, cross-cultural adaptation and validation of the Myasthenia Gravis Composite scale. A multicentric study

Author(s)

Oliveira, Ezequiel Fernandes ; Lima, Valeria Cavalcante ; Perez, Eduardo Araujo ; Polaro, Melissa Nunes ; Oliveira Valerio, Berenice Cataldo ; Pereiro, Joao R. ; Nacif, Sergio Roberto ; Oliveira, Claudia Santos ; Bulle Oliveira, Acary Souza ; Franco Oliveira, Luis Vicente

• Document type: Journal article
• Source: Arquivos de Neuro-Psiquiatria; v. 74, n. 11, p. 914-920, NOV 2016.
• Web of Science Citations: 2

Abstract

ABSTRACT Objective To perform the translation, cultural adaptation and validation of the Myasthenia Gravis Composite (MGC) scale in Brazil. Methods The study was conducted at three neuromuscular disease research centers in accordance with the international ethical standards, following a multi-modal approach and was conducted in three steps consisting of translation, cultural adaptation, and validation according to international guidelines. The final version of the MGC was applied in a sample of 27 MG patients and the total score was compared to a Portuguese version of the MG-QOL-15. Results The internal consistency verified by Cohen’s Kappa test was excellent (0.766). The correlation between the MGC and MG-QOL-15 was strong (R = 0.777; p = 0.000). No significant differences were found between the responses of patients in the first and second applications of the MGC. Conclusion The MGC scale, validated into Brazilian Portuguese, has proven to be a reliable instrument that is easy to use, and is highly reproducible. (AU)

• FAPESP's process: 15/11738-6 - Sleep study, lung function, respiratory muscle strength and validation of two instruments of clinical outcome in patients with myasthenia gravis: Myasthenia gravis Quantitative testing form and MG Composite Scale.
• Grantee: Ezequiel Fernandes de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate