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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of Structural Features on the Cellular Uptake Behavior of Non-Targeted Polyester-Based Nanocarriers

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Author(s):
de Castro, Carlos E. ; Bonvent, Jean-Jacques ; da Silva, Maria C. C. ; Castro, Fabiane L. F. ; Giacomelli, Fernando C.
Total Authors: 5
Document type: Journal article
Source: Macromolecular Bioscience; v. 16, n. 11, p. 1643-1652, NOV 2016.
Web of Science Citations: 3
Abstract

The development of delivery systems efficiently uptaken by cells is of due importance since sites of drug action are generally localized in subcellular compartments. Herein, naked and core-shell polymeric nanoparticles (NPs) have been produced from poly(lactic-co-glycolic acid)-PLGA, poly(ethylene oxide)-b-poly(e-caprolactone)-PEO-b-PCL, and poly(ethylene oxide)-b-poly(lactic acid)-PEO-b-PLA. The nanostructures are characterized and the cellular uptake behavior is evaluated. The data evidence that cellular uptake is enhanced as the length of the hydrophilic PEO-stabilizing shell reduces and that high negative surface charge restricts cellular uptake. Furthermore, NPs of higher degree of hydrophobicity (PEO-b-PCL) are more efficiently internalized as compared to PEO-b-PLA NPs. Accordingly, taking into account our recent published results({[}1]) and the findings of the current investigation, there should be a compromise regarding protein fouling and cellular uptake as resistance to nonspecific protein adsorption and enhanced cellular uptake are respectively directly and inversely related to the length of the PEO-stabilizing shell. (AU)

FAPESP's process: 14/22983-9 - Development of nanostructured supramolecular polymer systems based on cationic block copolymer/DNA complexation with potential application in gene delivery
Grantee:Fernando Carlos Giacomelli
Support Opportunities: Regular Research Grants
FAPESP's process: 15/24686-4 - THE INFLUENCE OF SURFACE CHEMISTRY AND PROTEIN CORONA IN THE CELLULAR UPTAKE OF NON-TARGETED POLYMERIC NANOPARTICLES
Grantee:Carlos Eduardo de Castro
Support Opportunities: Scholarships in Brazil - Doctorate