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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Unraveling the Anticancer Effect of Curcumin and Resveratrol

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Author(s):
Pavan, Aline Renata ; Bernardes da Silva, Gabriel Dalio ; Jornada, Daniela Hartmann ; Chiba, Diego Eidy ; dos Santos Fernandes, Guilherme Felipe ; Chin, Chung Man ; dos Santos, Jean Leandro
Total Authors: 7
Document type: Review article
Source: NUTRIENTS; v. 8, n. 11 NOV 2016.
Web of Science Citations: 33
Abstract

Resveratrol and curcumin are natural products with important therapeutic properties useful to treat several human diseases, including cancer. In the last years, the number of studies describing the effect of both polyphenols against cancer has increased; however, the mechanism of action in all of those cases is not completely comprehended. The unspecific effect and the ability to interfere in assays by both polyphenols make this challenge even more difficult. Herein, we analyzed the anticancer activity of resveratrol and curcumin reported in the literature in the last 11 years, in order to unravel the molecular mechanism of action of both compounds. Molecular targets and cellular pathways will be described. Furthermore, we also discussed the ability of these natural products act as chemopreventive and its use in association with other anticancer drugs. (AU)

FAPESP's process: 15/19531-1 - Targeting histone deacetylase (HDAC-1 and HDAC-2) as mechanisms to induce fetal hemoglobin in sickle cell disease
Grantee:Jean Leandro dos Santos
Support Opportunities: Regular Research Grants
FAPESP's process: 16/08470-4 - DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW DERIVATIVES OF LAPDESF FTD-AO AND LAPDESF FTD-TAU SERIES WITH POTENTIAL ACTIVITY IN THE TREATMENT OF ALZHEIMER'S DISEASE
Grantee:Diego Eidy Chiba
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/14980-0 - Drug design, synthesis and biological evaluation of hibrids with potential activity on the Alzheimer's Disease treatment
Grantee:Chung Man Chin
Support Opportunities: Regular Research Grants
FAPESP's process: 15/21252-3 - Synthesis and Pharmacological evaluation of new thalidomide/pomalidomide analogues regulators of epigenetic mechanisms
Grantee:Aline Renata Pavan
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 14/24811-0 - Design and synthesis of new 1,4-di-N-oxide quinoxaline as antitubercular compounds to treat multi drug-resistant (MDR) and latent tuberculosis
Grantee:Guilherme Felipe dos Santos Fernandes
Support Opportunities: Scholarships abroad - Research Internship - Master's degree
FAPESP's process: 14/02240-1 - Design, Synthesis and anti Mycobacterium tuberculosis activity of new N-oxides derivatives
Grantee:Guilherme Felipe dos Santos Fernandes
Support Opportunities: Scholarships in Brazil - Master