Unraveling the Anticancer Effect of Curcumin and Resveratrol

Author(s)

Pavan, Aline Renata ; Bernardes da Silva, Gabriel Dalio ; Jornada, Daniela Hartmann ; Chiba, Diego Eidy ; dos Santos Fernandes, Guilherme Felipe ; Chin, Chung Man ; dos Santos, Jean Leandro

• Document type: Review article
• Source: NUTRIENTS; v. 8, n. 11 NOV 2016.
• Web of Science Citations: 33

Abstract

Resveratrol and curcumin are natural products with important therapeutic properties useful to treat several human diseases, including cancer. In the last years, the number of studies describing the effect of both polyphenols against cancer has increased; however, the mechanism of action in all of those cases is not completely comprehended. The unspecific effect and the ability to interfere in assays by both polyphenols make this challenge even more difficult. Herein, we analyzed the anticancer activity of resveratrol and curcumin reported in the literature in the last 11 years, in order to unravel the molecular mechanism of action of both compounds. Molecular targets and cellular pathways will be described. Furthermore, we also discussed the ability of these natural products act as chemopreventive and its use in association with other anticancer drugs. (AU)

• FAPESP's process: 15/19531-1 - Targeting histone deacetylase (HDAC-1 and HDAC-2) as mechanisms to induce fetal hemoglobin in sickle cell disease
• Grantee: Jean Leandro dos Santos
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/08470-4 - DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW DERIVATIVES OF LAPDESF FTD-AO AND LAPDESF FTD-TAU SERIES WITH POTENTIAL ACTIVITY IN THE TREATMENT OF ALZHEIMER'S DISEASE
• Grantee: Diego Eidy Chiba
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 14/14980-0 - Drug design, synthesis and biological evaluation of hibrids with potential activity on the Alzheimer's Disease treatment
• Grantee: Chung Man Chin
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/21252-3 - Synthesis and Pharmacological evaluation of new thalidomide/pomalidomide analogues regulators of epigenetic mechanisms
• Grantee: Aline Renata Pavan
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 14/24811-0 - Design and synthesis of new 1,4-di-N-oxide quinoxaline as antitubercular compounds to treat multi drug-resistant (MDR) and latent tuberculosis
• Grantee: Guilherme Felipe dos Santos Fernandes
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• FAPESP's process: 14/02240-1 - Design, Synthesis and anti Mycobacterium tuberculosis activity of new N-oxides derivatives
• Grantee: Guilherme Felipe dos Santos Fernandes
• Support Opportunities: Scholarships in Brazil - Master