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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Gomesin acts in the immune system and promotes myeloid differentiation and monocyte/macrophage activation in mouse

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Buri, Marcus V. ; Dias, Carol C. ; Barbosa, Christiano M. V. ; Nogueira-Pedro, Amanda ; Ribeiro-Filho, Antonio C. ; Miranda, Antonio ; Paredes-Gamero, Edgar J.
Total Authors: 7
Document type: Journal article
Source: Peptides; v. 85, p. 41-45, NOV 2016.
Web of Science Citations: 3

Due to the cytotoxic effect of antimicrobial peptides (AMP) against several microorganism and tumor cells has been proposed their association with the immune system. However, just a few reports have shown this relationship. In this study, mice were treated with gomesin, a beta-hairpin AMP that exhibit high cytotoxicity against bacterial and tumor cells. Different effects in the immune system were observed, such as, decrease of CD3(+) in T lymphocytes (Control: 17.7 +/- 1.4%; Gomesin: 7.67 +/- 11.2%) and in hematopoietic progenitors and increase of hematopoietic stem cell (Control: 0.046 +/- 0.004%; Gomesin: 0.067 +/- 10.003%), B220(+) B lymphocytes (Control: 38.63 +/- 1.5%; Gomesin: 47.83 +/- 0.48%), and Mac-1(+)F4/80(+) macrophages (Control: 11.76 +/- 3.4%; Gomesin: 27.13 +/- 4.0%). Additionally, macrophage increase was accompanied by an increase of macrophage phagocytosis (Control 20.85 +/- 1.53; Gomesin 31.32 +/- 1 Geometric mean), interleukin 6 (Control: 47.24 +/- 1.9 ng/mL; Gomesin: 138.68 +/- 33.68 ng/mL) and monocyte chemoattractant protein-1 (Control: 0.872 +/- 0.093 ng/mL; Gomesin: 1.83 +/- 0.067 ng/mL). Thus, this report showed immunomodulatory activity of gomesin in the immune system of mice. (C) 2016 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 13/09068-7 - Action of hematopoietic modulators in leukemic stem cells
Grantee:Edgar Julian Paredes-Gamero
Support type: Regular Research Grants
FAPESP's process: 12/20989-4 - Molecular mechanisms studies in differentiation and cell death by antimicrobial peptides using leukemic and adenocarcinoma cells
Grantee:Marcus Vinicius Buri
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/22901-5 - Photothermal heterodyne image Microscopy single molecule tracking of antimicrobial peptide
Grantee:Marcus Vinicius Buri
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 11/17584-0 - Studies of the structure-activity relationship and mechanism of lytic action of the antimicrobial peptide gomesin
Grantee:Antonio de Miranda
Support type: Regular Research Grants