Action of hematopoietic modulators in leukemic stem cells

• Grant number: 13/09068-7
• Support type: Regular Research Grants
• Duration: November 01, 2013 - October 31, 2015
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Edgar Julian Paredes-Gamero
• Grantee: Edgar Julian Paredes-Gamero
• Home Institution: Pró-Reitoria de Pesquisa, Pós-Graduação e Extensão. Universidade de Mogi das Cruzes (UMC). Mogi das Cruzes , SP, Brazil

Abstract

The hematopoietic stem cells (HSCs) are responsible for generating all cells of hematopoietic tissue. Concerning leukemias, mutations that affect the control of proliferation and differentiation of HSCs can cause this kind of cancer. It was postulated that leukemia is originated by mutations in HSCs generating leukemic stem cells (LSCs) maintaining some features such as quiescence and undifferentiated immunophenotype. Extracellular ATP, which acts by activation of P2 receptors, was able to induce differentiation of HSC. This capability is being explored against LSCs. Furthermore, another group of molecules known as antimicrobial peptides has also demonstrated its cytotoxic ability against leukemias. The purpose of this project is to continue with our studies investigating the action of extracellular ATP and antimicrobial peptides against CTL. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BURI, MARCUS V.; VIEIRA TORQUATO, HERON F.; BARROS, CARLOS CASTILHO; IDE, JAIME S.; MIRANDA, ANTONIO; PAREDES-GAMERO, EDGAR J. Comparison of Cytotoxic Activity in Leukemic Lineages Reveals Important Features of beta-Hairpin Antimicrobial Peptides. Journal of Cellular Biochemistry, v. 118, n. 7, p. 1764-1773, JUL 2017. Web of Science Citations: 8.

TORQUATO, HERON F. V.; GOETTERT, MARCIA I.; JUSTO, GISELLE Z.; PAREDES-GAMERO, EDGAR J. Anti-Cancer Phytometabolites Targeting Cancer Stem Cells. CURRENT GENOMICS, v. 18, n. 2, p. 156-174, 2017. Web of Science Citations: 8.

BURI, MARCUS V.; DIAS, CAROL C.; BARBOSA, CHRISTIANO M. V.; NOGUEIRA-PEDRO, AMANDA; RIBEIRO-FILHO, ANTONIO C.; MIRANDA, ANTONIO; PAREDES-GAMERO, EDGAR J. Gomesin acts in the immune system and promotes myeloid differentiation and monocyte/macrophage activation in mouse. Peptides, v. 85, p. 41-45, NOV 2016. Web of Science Citations: 3.

RIBEIRO-FILHO, ANTONIO CARLOS; BURI, MARCUS VINICIUS; BARROS, CARLOS CASTILHO; DREYFUSS, JULIANA LUPORINI; NADER, HELENA BONCIANI; JUSTO, GISELLE ZENKER; CRAVEIRO, ROGERIO BASTOS; PESQUERO, JOAO BOSCO; MIRANDA, ANTONIO; FERREIRA, ALICE TEIXEIRA; PAREDES-GAMERO, EDGAR JULIAN. Functional and molecular evidence for heteromeric association of P2Y(1) receptor with P2Y(2) and P2Y(4) receptors in mouse granulocytes. BMC PHARMACOLOGY & TOXICOLOGY, v. 17, JUL 7 2016. Web of Science Citations: 1.

DIAS, CAROLINA C.; NOGUEIRA-PEDRO, AMANDA; TOKUYAMA, PAULA YUMI; MARTINS, MARTA N. C.; COMODO SEGRETO, HELENA REGINA; BURI, MARCUS V.; MIRANDA, ANTONIO; PAREDES-GAMERO, EDGAR J. A Synthetic Fragment of Leptin Increase Hematopoietic Stem Cell Population and Improve Its Engraftment Ability. Journal of Cellular Biochemistry, v. 116, n. 7, p. 1334-1340, JUL 2015. Web of Science Citations: 2.