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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene)

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Author(s):
Campos, Estefania V. R. ; Oliveira, Jhones L. ; Zavala-Betancourt, Sara A. ; Ledezma, Antonio S. ; Arias, Eduardo ; Moggio, Ivana ; Romero, Jorge ; Fraceto, Leonardo F.
Total Authors: 8
Document type: Journal article
Source: COLLOIDS AND SURFACES B-BIOINTERFACES; v. 147, p. 442-449, NOV 1 2016.
Web of Science Citations: 2
Abstract

A phenyleneethynylene polymer (here denoted pPy3E-sqS) was synthesized and characterized by UV-vis spectroscopy, fluorescence spectroscopy, and TEM, and was used for the staining of polymeric nanocapsules. The nanocapsules presented good temporal stability, without changes in shape or fluorescence, and were suitable for use in drug release systems. The mean particle size was around 430 nm, the polydispersity index was below 0.2, and the zeta potential was around -13 mV. The release kinetics is one of the most important factors to consider in drug delivery systems, and here it was observed that nanocapsules containing the fluorescent polymer still maintained the ability to modulate the release of the fungicides tebuconazole and carbendazim (used as model drugs) after 4 days. Preliminary results indicated that staining with the fluorescent pPy3E-sqS polymer could be used as a valuable tool to track the behavior of polymeric systems in the environment. However, further studies will be needed to clarify the environmental behavior and possible toxicity. (C) 2016 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 14/20286-9 - Development of modified release systems based on zein and chitosan for botanical repellents aiming the control of whitefly (Bemisia tabaci) in different cultures
Grantee:Jhones Luiz de Oliveira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/15617-9 - Botanical repellents and nanotechnology: development of systems for pest control in agriculture
Grantee:Leonardo Fernandes Fraceto
Support type: Regular Research Grants
FAPESP's process: 14/20273-4 - Development of chitosan-²-cyclodextrin nanoparticles for sustained release of carvacrol and linalool aiming agricultural applications
Grantee:Estefânia Vangelie Ramos Campos
Support type: Scholarships in Brazil - Doctorate