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Development of chitosan-²-cyclodextrin nanoparticles for sustained release of carvacrol and linalool aiming agricultural applications

Grant number: 14/20273-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2015
Effective date (End): February 28, 2018
Field of knowledge:Biological Sciences - Biochemistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Leonardo Fernandes Fraceto
Grantee:Estefânia Vangelie Ramos Campos
Home Institution: Instituto de Ciência e Tecnologia. Universidade Estadual Paulista (UNESP). Campus de Sorocaba. Sorocaba , SP, Brazil


The largest agricultural losses worldwide are related to insects and pests that affect diverse cultures, causing damage that can reach up to 100% loss in severe cases. The velvetbean caterpillar (gemmatalis Anticarsia) and fall armyworm corn (Spodoptera fugiperda) are the main pests on two cultures of great importance for the Brazilian agribusiness, soybeans and corn respectively. The use of synthetic insecticides to control these pests, although efficient, have a number of problems, from environmental contamination and emergence of resistant populations of insects to human contamination. In this context, an alternative that has been resumed for pest control is the use of secondary metabolites in some plants, which, given the name of insecticidal plants, which have been effective in controlling these. However, botanical insecticides have some limitations, such as instability problems that can be overcome employing modified release systems. In this context, the objective of the project is to prepare and characterize chitosan nanoparticles functionalized with cyclodextrin to load the botanical insecticide (carvacrol) and the botanical replente (linalool) and later the incorporation of these nanoparticles in gels for the production of devices aiming at applications in agriculture. Furthermore, we will investigate the cytotoxicity and phytotoxicity of prepared systems, as well as bioassays of insecticidal and repellent activity against target species (Spodoptera gemmatalis and Anticarsia fugiperda). The size of this project lies in the fact that Brazil is the main consumer of agricultural inputs in the world, due to the need of quality production, since agriculture is essential for the Brazilian economy. Thus, development of value-added systems for pest control based on sustained release systems for insecticides /repellents more effective and less impactful botanical against the conventional systems currently used for pest control in agriculture. (AU)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAMPOS, ESTEFANIA V. R.; PROENCA, PATRICIA L. F.; OLIVEIRA, JHONES L.; BAKSHI, MANSI; ABHILASH, P. C.; FRACETO, LEONARDO F. Use of botanical insecticides for sustainable agriculture: Future perspectives. ECOLOGICAL INDICATORS, v. 105, p. 483-495, OCT 2019. Web of Science Citations: 7.
SIBAJA LUIS, ANGELICA IRASEMA; RAMOS CAMPOS, ESTEFANIA VANGELIE; DE OLIVEIRA, JHONES LUIZ; FRACETO, LEONARDO FERNANDES. Trends in aquaculture sciences: from now to use of nanotechnology for disease control. Reviews in Aquaculture, v. 11, n. 1, p. 119-132, FEB 2019. Web of Science Citations: 4.
CAMPOS, ESTEFANIA V. R.; PROENCA, PATRICIA L. F.; OLIVEIRA, JHONES L.; PEREIRA, ANDERSON E. S.; DE MORAIS RIBEIRO, LIGIA NUNES; FERNANDES, FABRICIO O.; GONCALVES, KELLY C.; POLANCZYK, RICARDO A.; PASQUOTO-STIGLIANI, TATIANE; LIMA, RENATA; MELVILLE, CIRANO C.; DELLA VECHIA, JAQUELINE F.; ANDRADE, DANIEL J.; FRACETO, LEONARDO F. Carvacrol and linalool co-loaded in beta-cyclodextrin-grafted chitosan nanoparticles as sustainable biopesticide aiming pest control. SCIENTIFIC REPORTS, v. 8, MAY 16 2018. Web of Science Citations: 13.
CAMPOS, ESTEFNIA V. R.; OLIVEIRA, JHONES L.; FRACETO, LEONARDO F. Poly(ethylene glycol) and Cyclodextrin-Grafted Chitosan: From Methodologies to Preparation and Potential Biotechnological Applications. FRONTIERS IN CHEMISTRY, v. 5, NOV 7 2017. Web of Science Citations: 3.
JACQUES, MAURICIO T.; OLIVEIRA, JHONES L.; CAMPOS, ESTEFANIA V. R.; FRACETO, LEONARDO F.; AVILA, DAIANA SILVA. Safety assessment of nanopesticides using the roundworm Caenorhabditis elegans. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v. 139, p. 245-253, MAY 2017. Web of Science Citations: 18.
CAMPOS, ESTEFANIA V. R.; OLIVEIRA, JHONES L.; ZAVALA-BETANCOURT, SARA A.; LEDEZMA, ANTONIO S.; ARIAS, EDUARDO; MOGGIO, IVANA; ROMERO, JORGE; FRACETO, LEONARDO F. Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene). COLLOIDS AND SURFACES B-BIOINTERFACES, v. 147, p. 442-449, NOV 1 2016. Web of Science Citations: 2.
CAMPOS, ESTEFANIA V. R.; DE OLIVEIRA, JHONES L.; PASCOLI, MONICA; DE LIMA, RENATE; FRACETO, LEONARDO F. Neem Oil and Crop Protection: From Now to the Future. FRONTIERS IN PLANT SCIENCE, v. 7, OCT 13 2016. Web of Science Citations: 16.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CAMPOS, Estefânia Vangelie Ramos. . 2018. Doctoral Thesis - Universidade Estadual de Campinas, Instituto de Biologia.

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