Lipidic nanoparticles as carrier systems for ivermectin and methoprene aiming veterinary applications

• Grant number: 13/24788-6
• Support type: Scholarships in Brazil - Master
• Effective date (Start): March 01, 2014
• Effective date (End): February 29, 2016
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal researcher: Leonardo Fernandes Fraceto
• Grantee: Diego Faria Cola
• Home Institution: Instituto de Ciência e Tecnologia. Universidade Estadual Paulista (UNESP). Campus de Sorocaba. Sorocaba , SP, Brazil

Abstract

In recent decades , the study of characteristics and applications of nanometer-scale structures began to take an interest to researchers in the medical, environmental and agricultural areas. Among these, the nanocarriers can improve the bioavailability of many bioactive compounds and reduction of potential toxicological effects. In this way, the development of new targeted nanocarriers to combat endo and ectoparasites that cause great losses to farmers is necessary. Chemical compounds such as ivermectin and Methoprene are used to combat ectoparasites. To improve the bioavailability of these compounds , we intend to prepare and characterize lipid carrier systems such as Solid Lipid Nanoparticles ( SLN) and nanostructured lipid carriers ( NLC ), which allowed the sustained release of these compounds . Analyzes will be conducted to investigate physical and chemical stability of formulations over time in order to develop new alternatives to control ectoparasites.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DIEGO FARIA COLA; TATIANE PASQUOTO; MARIANA GUILGER; RENATA DE LIMA; CAMILA MORAIS GONÇALVES DA SILVA; LEONARDO FERNANDES FRACETO. SISTEMAS CARREADORES LIPÍDICOS NANOESTRUTURADOS PARA IVERMECTINA E METOPRENO VISANDO CONTROLE DE PARASITAS. Química Nova, v. 39, n. 9, p. 1034-1043, 2016-11-00. (13/24788-6, 15/15617-9, 13/12322-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

COLA, Diego Faria. Lipid nanoparticles as carrier systems for Ivermectin and Methoprene aiming veterinary applications. 2016. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Ciência e Tecnologia. Sorocaba Sorocaba.