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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Immunomodulatory/anti-inflammatory effects of a propolis-containing mouthwash on human monocytes

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Author(s):
Santiago, Karina Basso ; Conti, Bruno Jose ; Cardoso, Eliza de Oliveira ; Golim, Marjorie de Assis ; Sforcin, Jose Mauricio
Total Authors: 5
Document type: Journal article
Source: PATHOGENS AND DISEASE; v. 74, n. 8 NOV 2016.
Web of Science Citations: 4
Abstract

Propolis is a bee product used in folk medicine to improve health and prevent inflammatory diseases. It has attracted the attention of researchers from the odontological field lately, reducing inflammation resulting from surgical procedures and as an antimicrobial agent in the control of bacterial plaque. Thus far, no side-effects that might compromise oral health have been observed. Chlorhexidine is an antimicrobial agent widely used as an antiseptic, but side-effects restrict its use. This work investigated the effects of an odontological product containing propolis in combination with chlorhexidine in lower concentrations on human monocytes. Cell marker expression, the nuclear factor kappa B (NF-kappa B) signaling pathway, the production of pro-and anti-inflammatory cytokines, and the bactericidal activity of these cells against Streptococcus mutans were evaluated. Data showed that the combination of propolis and chlorhexidine may favor the recognition of antigens by monocytes, slightly activates the NF-kappa B signaling pathway, and increases the bactericidal activity of human monocytes against S. mutans. Also, the combination played a role in anti-inflammatory cytokine production, which can be beneficial in the treatment of periodontal diseases. These results may have implications for the development of odontological products with immunomodulatory/anti-inflammatory action, and may have further-reaching implications for the pharmaceutical industry. (AU)

FAPESP's process: 12/14614-8 - THE ASSOCIATION OF PROPOLIS AND ODONTOLOGICAL PRODUCTS ON HUMAN MONOCYTES ACTIVITY
Grantee:José Maurício Sforcin
Support Opportunities: Regular Research Grants
FAPESP's process: 11/22112-0 - CHARACTERIZATION OF A PROPOLIS-BASED ODONTOLOGICAL PRODUCT: ANTIBACTERIAL AND IMMUNOMODULATORY ACTIONS
Grantee:Karina Basso Santiago
Support Opportunities: Scholarships in Brazil - Doctorate