Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prefrontal-Parietal White Matter Volumes in Healthy Elderlies Are Decreased in Proportion to the Degree of Cardiovascular Risk and Related to Inhibitory Control Deficits

Full text
Author(s):
Souza-Duran, Fabio L. [1, 2] ; Rzezak, Patricia [12]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Dept & Inst Psychiat, Sao Paulo, Brazil. Menezes, Paulo R., Univ Sao Paulo, Fac Med, Dept Prevent Med, Sao Paulo, Brazil. Menezes, Paulo R., Univ Sao Paulo, Ctr Res Mental Hlth Populat, Sao Paulo, Brazil. Leite, Claudia Da Costa, Univ Sao - Brazil
[2] Busatto, Geraldo F., Univ Sao Paulo, Lab Psychiat Neuroimaging, Inst \& Dept Psychiat, Sao Paulo, Brazil. Santos, Pedro P., Univ Sao Paulo, Dept & Inst Psychiat, Sao Paulo, Brazil. Menezes, Paulo R., Univ Sao Paulo, Fac Med, Dept Prevent Med, Sao Paulo, B - Brazil
[3] Univ Sao Paulo, Dept & Inst Psychiat, Sao Paulo, Brazil. Menezes, Paulo R., Univ Sao Paulo, Fac Med, Dept Prevent Med, Sao Paulo, Brazil. Menezes, Paulo R., Univ Sao Paulo, Ctr Res Mental Hlth Populat, Sao Paulo, Brazil. Leite, Claudia Da Costa, Univ Sao Paulo, Lab Magnet Resonance Neuroradiol, Inst & Dept Radiol, Sao Paulo, Brazil. Lotufo, Paulo A., Univ Sao Paulo, Dept Internal Med, Ctr Clin & Epidemiol Res, Sao Paulo, Brazil. Wajngarten, Mauricio, Univ Sao Paulo, Sch Med, Dept Cardiopneumol, Heart Inst, Gen Hosp, Sao Paulo, Brazil. Rzezak, Patricia, Univ Sao Paulo, Med Sch IPq HC FMUSP, Lab Clin Neurophysiol, Inst Psychiat, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: FRONTIERS IN PSYCHOLOGY; v. 8, JAN 26 2017.
Web of Science Citations: 1
Abstract

Cardiovascular risk (CVR) factors may be associated with poor cognitive functioning in elderlies and impairments in brain structure. Using MRI and voxel-based morphometry (VBM), we assessed regional white matter (WM) volumes in a population-based sample of individuals aged 65-75 years (n = 156), subdivided in three CVR subgroups using the Framingham Risk Score. Cognition was assessed using the Short Cognitive Performance Test. In high-risk subjects, we detected significantly reduced WM volume in the right juxtacortical dorsolateral prefrontal region compared to both low and intermediate CVR subgroups. Findings remained significant after accounting for the presence of the APOE epsilon 4 allele. Inhibitory control performance was negatively related to right prefrontal WM volume, proportionally to the degree of CVR. Significantly reduced deep parietal WM was also detected bilaterally in the high CVR subgroup. This is the first large study documenting the topography of CVR-related WM brain volume deficits. The significant association regarding poor response inhibition indicates that prefrontal WM deficits related to CVR are clinically meaningful, since inhibitory control is known to rely on prefrontal integrity. (AU)

FAPESP's process: 12/50329-6 - Translational neuroscience of Alzheimer's disease: preclinical and clinical studies of b-amyloid peptide and other biomarkers
Grantee:Geraldo Busatto Filho
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 04/15336-5 - Brain abnormalities associated with cardiovascular risk factors: a population-based study using voxel-a-voxel morphometry by magnetic resonance and measures of glucose metabolism by positron-emission tomography
Grantee:Geraldo Busatto Filho
Support Opportunities: Regular Research Grants