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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neuroimmune interactions: dendritic cell modulation by the sympathetic nervous system

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Author(s):
Takenaka, Maisa C. ; Guereschi, Marcia G. ; Basso, Alexandre S.
Total Authors: 3
Document type: Review article
Source: SEMINARS IN IMMUNOPATHOLOGY; v. 39, n. 2, p. 165-176, FEB 2017.
Web of Science Citations: 8
Abstract

Dendritic cells are of paramount importance bridging innate and adaptive immune responses. Depending on the context, after sensing environmental antigens, commensal microorganisms, pathogenic agents, or antigens from the diet, dendritic cells may drive either different effector adaptive immune responses or tolerance, avoiding tissue damage. Although the plasticity of the immune response and the capacity to regulate itself are considered essential to orchestrate appropriate physiological responses, it is known that the nervous system plays a relevant role controlling immune cell function. Dendritic cells present in the skin, the intestine, and lymphoid organs, besides expressing adrenergic receptors, can be reached by neurotransmitters released by sympathetic fibers innervating these tissues. These review focus on how neurotransmitters from the sympathetic nervous system can modulate dendritic cell function and how this may impact the immune response and immune-mediated disorders. (AU)

FAPESP's process: 14/24156-2 - Alfa2a/c adrenergic receptors-deficient mice as an animal model to study the influence of the sympathetic nervous system on the experimental autoimmune encephalomyelitis development
Grantee:Alexandre Salgado Basso
Support Opportunities: Regular Research Grants
FAPESP's process: 13/13110-9 - Catecholamine production by Foxp3+ Regulatory T cells and its role in Treg cells differentiation and suppressive function in vitro and in vivo.
Grantee:Marcia Grando Guereschi
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 08/58564-9 - Study of adaptive immune response modulation by the sympathetic nervous system: emphasis on autoimmunity, Th17 cells and Foxp3 + regulatory T cells
Grantee:Alexandre Salgado Basso
Support Opportunities: Research Grants - Young Investigators Grants