Study of adaptive immune response modulation by the sympathetic nervous system: emphasis on autoimmunity, Th17 cells and Foxp3 + regulatory T cells

• Grant number: 08/58564-9
• Support Opportunities: Research Grants - Young Investigators Grants
• Duration: July 01, 2009 - June 30, 2014
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Alexandre Salgado Basso
• Grantee: Alexandre Salgado Basso
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated grant(s): 13/06586-7 - 15th International Congress of Immunology, AR.EXT
• Associated scholarship(s): 13/13110-9 - Catecholamine production by Foxp3+ Regulatory T cells and its role in Treg cells differentiation and suppressive function in vitro and in vivo., BP.PD; 11/02738-1 - Modulation of experimental autoimmune encephalomyelitis by the sympathetic nervous system, BP.DR; 10/13451-2 - The role of catecholamines and neuropeptide Y on dendritic cell function, BP.MS

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GUERESCHI, MARCIA G.; ARAUJO, LEANDRO P.; MARICATO, JULIANA T.; TAKENAKA, MAISA C.; NASCIMENTO, VANESSA M.; VIVANCO, BRUNO C.; REIS, VANESSA O.; KELLER, ALEXANDRE C.; BRUM, PATRICIA C.; BASSO, ALEXANDRE S.. Beta2-adrenergic receptor signaling in CD4(+) Foxp3(+) regulatory T cells enhances their suppressive function in a PKA-dependent manner. European Journal of Immunology, v. 43, n. 4, p. 1001-1012, APR 2013. (09/51886-3, 08/58564-9)

ARAUJO, LEANDRO PIRES; MARICATO, JULIANA TERZI; GUERESCHI, MARCIA GRANDO; TAKENAKA, MAISA CARLA; NASCIMENTO, VANESSA M.; DE MELO, FILIPE MENEGATTI; QUINTANA, FRANCISCO J.; BRUM, PATRICIA C.; BASSO, ALEXANDRE S.. The Sympathetic Nervous System Mitigates CNS Autoimmunity via beta 2-Adrenergic Receptor Signaling in Immune Cells. CELL REPORTS, v. 28, n. 12, p. 3120+, SEP 17 2019. (11/02738-1, 14/24156-2, 08/58564-9)

TAKENAKA, MAISA CARLA; ARAUJO, LEANDRO PIRES; MARICATO, JULIANA TERZI; NASCIMENTO, VANESSA M.; GUERESCHI, MARCIA GRANDO; REZENDE, RAFAEL MACHADO; QUINTANA, FRANCISCO J.; BASSO, ALEXANDRE S.. Norepinephrine Controls Effector T Cell Differentiation through beta 2-Adrenergic Receptor-Mediated Inhibition of NF-kappa B and AP-1 in Dendritic Cells. JOURNAL OF IMMUNOLOGY, v. 196, n. 2, p. 637-644, JAN 15 2016. (08/58564-9)

MORAES-VIEIRA, PEDRO M. M.; LAROCCA, RAFAEL A.; BASSI, ENIO J.; PERON, JEAN PIERRE S.; ANDRADE-OLIVEIRA, VINICIUS; WASINSKI, FREDERICK; ARAUJO, RONALDO; THORNLEY, THOMAS; QUINTANA, FRANCISCO J.; BASSO, ALEXANDRE S.; et al. Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells. European Journal of Immunology, v. 44, n. 3, p. 794-806, MAR 2014. (09/50450-7, 08/58564-9)

MORAES-VIEIRA, P. M. M.; BASSI, E. J.; LAROCCA, R. A.; CASTOLDI, A.; BURGHOS, M.; LEPIQUE, A. P.; QUINTANA, F. J.; ARAUJO, R. C.; BASSO, A. S.; STROM, T. B.; et al. Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile. AMERICAN JOURNAL OF TRANSPLANTATION, v. 13, n. 1, p. 36-44, JAN 2013. (07/07139-3, 12/02270-2, 09/50450-7, 08/58564-9)

TAKENAKA, MAISA C.; GUERESCHI, MARCIA G.; BASSO, ALEXANDRE S.. Neuroimmune interactions: dendritic cell modulation by the sympathetic nervous system. SEMINARS IN IMMUNOPATHOLOGY, v. 39, n. 2, p. 165-176, FEB 2017. (14/24156-2, 13/13110-9, 08/58564-9)