Relationship Between Adiposity Indices, Lipodystrophy, and Sarcopenia in HIV-Positive Individuals With and Without Lipodystrophy

Author(s)

Mialich, Mirele Savegnago ; dos Santos, Andre Pereira ; da Silva, Bruna Ramos ; Albuquerque de Paula, Francisco Jose ; Jordao, Alceu Afonso ; Navarro, Anderson Marliere

• Document type: Journal article
• Source: JOURNAL OF CLINICAL DENSITOMETRY; v. 20, n. 1, p. 73-81, JAN-MAR 2017.
• Web of Science Citations: 5

Abstract

Metabolism disorders, as well as body shape abnormalities, have been associated with the introduction of antiretroviral therapy. The objective of this study was to compare the diagnostic ability of adiposity indices and to discuss criteria for the classification of lipodystrophy and sarcopenia (SP) in HIV-positive individuals. Anthropometric measurements were determined in 268 individuals of both genders, also submitted to the dual-energy X-ray absorptiometry exam. The adiposity indices calculated were body mass index, body mass index adjusted for fat mass (BMIfat), body adiposity index, body adiposity Index for the Fels Longitudinal Study sample, and The Clinica Universidad de Navarra body adiposity estimator. The presence of lipodystrophy was evaluated using the fat mass ratio (FMR). SP was classified using the appendicular lean mass/height(2) ratio. The subjects were divided into 3 groups: HIV+LIPO+ (n = 41), HIV+LIPO- (n = 65), and control (C, HIV-negative individuals; n = 162). Among the adiposity indices assessed, BMIfat showed the strongest correlation with total body fat (in percent) for men (r = 0.87,p < 0.001) and women (r = 0.92,p < 0.001). The frequency of SP was 44.8% and 41.7% in HIV+LIPO-, 27.8% and 20.7% in HIV+LIPO- and 63.3% and 45.45% in C, for men and women, respectively. The cutoff point suggested for the diagnosis of lipodystrophy according to the FMR was 1.14. The adiposity indices, particularly the BMIfat, have strong correlation with body fat determined by dual-energy X-ray absorptiometry in HIV-positive patients. The implementation of FMR is recommended for more standardized estimates of the frequency of lipodystrophy. (AU)

• FAPESP's process: 12/15944-1 - Improvement of BMI reference values for the classification of nutritional status in a sample of the Brazilian population
• Grantee: Mirele Savegnago Mialich Grecco
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/18536-7 - Evaluation of the accuracy of methods for the prediction of body fat in a Brazilian sample
• Grantee: Bruna Ramos da Silva
• Support Opportunities: Scholarships in Brazil - Scientific Initiation