| Full text | |
| Author(s): Show less - |
Rodrigues Silva, Vagner Ramon
;
Katashima, Carlos Kiyoshi
;
Bueno Silva, Carla G.
;
Lenhare, Luciene
;
Micheletti, Thayana Oliveira
;
Camargo, Rafael Ludemann
;
Ghezzi, Ana Carolina
;
Camargo, Juliana Alves
;
Assis, Alexandre Moura
;
Tobar, Natalia
;
Morari, Joseane
;
Razolli, Daniela S.
;
Moura, Leandro Pereira
;
Pauli, Jose Rodrigo
;
Cintra, Dennys Esper
;
Velloso, Licio Augusto
;
Saad, Mario J. A.
;
Ropelle, Eduardo Rochete
Total Authors: 18
|
| Document type: | Journal article |
| Source: | AGING-US; v. 9, n. 1, p. 156-169, JAN 2017. |
| Web of Science Citations: | 5 |
| Abstract | |
Recently, we demonstrated that the hypothalamic S1PR1/STAT3 axis plays a critical role in the control of food consumption and energy expenditure in rodents. Here, we found that reduction of hypothalamic S1PR1 expression occurs in an age-dependent manner, and was associated with defective thermogenic signaling and weight gain. To address the physiological relevance of these findings, we investigated the effects of chronic and acute exercise on the hypothalamic S1PR1/STAT3 axis. Chronic exercise increased S1PR1 expression and STAT3 phosphorylation in the hypothalamus, restoring the anorexigenic and thermogenic signals in middle-aged mice. Acutely, exercise increased sphingosine-1-phosphate (S1P) levels in the cerebrospinal fluid (CSF) of young rats, whereas the administration of CSF from exercised young rats into the hypothalamus of middle-aged rats at rest was sufficient to reduce the food intake. Finally, the intracerebroventricular (ICV) administration of S1PR1 activators, including the bioactive lipid molecule S1P, and pharmacological S1PR1 activator, SEW2871, induced a potent STAT3 phosphorylation and anorexigenic response in middle-aged rats. Overall, these results suggest that hypothalamic S1PR1 is important for the maintenance of energy balance and provide new insights into the mechanism by which exercise controls the anorexigenic and thermogenic signals in the central nervous system during the aging process. (AU) | |
| FAPESP's process: | 11/09656-0 - Characterization of hypothalamic S1PR1 in the control of food intake in rodents |
| Grantee: | Eduardo Rochete Ropelle |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 11/13828-1 - Effects of physical exercise on leptin signaling in the hypothalamus of rats: The role of neuronal S1PR1. |
| Grantee: | Vagner Ramon Rodrigues Silva |
| Support Opportunities: | Scholarships in Brazil - Master |