| Full text | |
| Author(s): |
Sabino, Joao Paulo J.
;
Soriano, Renato N.
;
Donatti, Alberto F.
;
Fernandez, Rodrigo Restrepo
;
Kwiatkoski, Marcelo
;
Francescato, Heloisa D. C.
;
Coimbra, Terezila M.
;
Branco, Luiz G. S.
Total Authors: 8
|
| Document type: | Journal article |
| Source: | Canadian Journal of Physiology and Pharmacology; v. 95, n. 2, p. 157-162, FEB 2017. |
| Web of Science Citations: | 1 |
| Abstract | |
Spontaneously hypertensive rats (SHR) display autonomic imbalance and abnormal body temperature (Tb) adjustments. Hydrogen sulfide (H2S) modulates hypoxia-induced hypothermia, but its role in SHR thermoregulation is unknown. We tested the hypothesis that SHR display peculiar thermoregulatory response to hypoxia and that endogenous H2S overproduced in the caudal nucleus of the solitary tract (NTS) of SHR modulates this response. SHR and Wistar rats were microinjected into the fourth ventricle with aminooxyacetate (AOA, H2S-synthezing enzyme inhibitor) or sodium sulfide (Na2S, H2S donor) and exposed to normoxia (21% inspired O-2) or hypoxia (10% inspired O-2, 30 min). Tb was continuously measured, and H2S production rate was assessed in caudal NTS homogenates. In both groups, AOA, Na2S, or saline (i.e., control; 1 mu L) did not affect euthermia. Hypoxia caused similar decreases in Tb in both groups. AOA presented a longer latency to potentiate hypoxic hypothermia in SHR. Caudal NTS H2S production rate was higher in SHR. We suggest that increased bioavailability of H2S in the caudal NTS of SHR enables the adequate modulation of excitability of peripheral chemoreceptor-activated NTS neurons that ultimately induce suppression of brown adipose tissue thermogenesis, thus accounting for the normal hypoxic hypothermia. (AU) | |
| FAPESP's process: | 11/14779-4 - Effect of hydrogen sulfide (H2S) in the commissural NTS on the ventilatory and hemodynamic response to hypoxia and hypercapnia in normotensive and hypertensive animals |
| Grantee: | João Paulo Jacob Sabino |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 15/24950-3 - Role of Hydrogen Sulphide (H2S) on the ventilatory responses to hypercapnia |
| Grantee: | Luiz Guilherme de Siqueira Branco |
| Support type: | Regular Research Grants |