Antiproliferative and ultrastructural effects of phenethylamine derivatives on promastigotes and amastigotes of Leishmania (Leishmania) infantum chagasi

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Brasil, Paula Ferreira ; de Freitas, Julia Araujo ; Silva Barreto, Anna Lea ; Adade, Camila Marques ; Reis de Sa, Leandro Figueira ; Constantino-Teles, Pamella ; Toledo, Fabiano Travanca ; de Sousa, Bruno A. ; Goncalves, Augusto Cesar ; Villela Romanos, Maria Teresa ; Comasseto, Joao V. ; dos Santos, Alcindo A. ; Tessis, Ana Claudia ; Souto-Padron, Thais ; Soares, Rosangela Maria A. ; Ferreira-Pereira, Antonio

• Document type: Journal article
• Source: Parasitology International; v. 66, n. 2, p. 47-55, APR 2017.
• Web of Science Citations: 5

Abstract

Leishmania (Leishmania) infantum chagasi is one of the agents that cause visceral leishmaniasis. This disease occurs more frequently in third world countries, such as Brazil. The treatment is arduous, and is dependent on just a few drugs like the antimonial derivatives and amphotericin B. Moreover, these drugs are not only expensive, but they can also cause severe side effects and require long-term treatment. Therefore, it is very important to find new compounds that are effective against leishmaniasis. In the present work we evaluated a new group of synthetic amides against the promastigote and amastigote forms of L infant= chagasi. The results showed that one of these amides in particular, presented very effective activity against the promastigotes and amastigotes of L infantum chagasi at low concentrations and it also presented low toxicity for mammal cells, which makes this synthetic amide a promising drug for combating leishmaniasis. (C) 2016 Elsevier Ireland Ltd. All rights reserved. (AU)

• FAPESP's process: 16/09579-0 - Synthesis of Organic Selenides and Tellurides for Detection and Interception of Endogenous Oxidants
• Grantee: Alcindo Aparecido dos Santos
• Support Opportunities: Regular Research Grants