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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis, characterization and preliminary antimicrobial assays of copper(II) complexes with 2-(imidazole-2-yl)heteroaryl ligands

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Author(s):
Nakahata, Douglas H. ; Ribeiro, Marcos A. ; Corbi, Pedro P. ; Machado, Daisy ; Lancellotti, Marcelo ; Lustri, Wilton R. ; da Costa Ferreira, Ana M. ; Formiga, Andre L. B.
Total Authors: 8
Document type: Journal article
Source: Inorganica Chimica Acta; v. 458, p. 224-232, MAR 24 2017.
Web of Science Citations: 6
Abstract

The coordination chemistry and antimicrobial profiles of three copper(II) complexes with 2-(imidazole-2yl)heteroaryl ligands, named impy, impz and impm, have been investigated. Based on X-ray structure determination the complexes present square planar geometry with coordination formulas {[}CuCl2(impx)], where x = y, z or m. Elemental analysis and mass spectrometric results are in agreement with the proposed compositions. Vibrational spectroscopy and molecular modeling provided further evidences that the {[}CuCl2(impz)] complex, which did not have its structure solved by X-ray diffraction, adopts a similar geometry of the other two complexes. Electronic spectroscopic data indicated that all three ligands led to a hypsochromic shift of the d-d band when compared to CuCl2.2H(2)O and that the electronic structure of the ligands are significantly altered upon coordination to Cu(II). Electronic paramagnetic resonance studies in solution showed that the compounds present similar coordination environments. The MIC values of the complexes over E. coli and S. aureus was 17.8 mu mol.mL(-1), thus no distinction was found between the complexes and the tested strain. The complexes were inactive over three tested fungal strains under the considered experimental conditions. (C) 2017 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 15/25114-4 - Synthesis of New Ag(I), Cu(II), Pd(II) and Pt(II) complexes based on sulfonamides and derivatives: antibacterial activities and application prospects on skin critically colonized wounds.
Grantee:Pedro Paulo Corbi
Support Opportunities: Regular Research Grants