Respiratory DNA viruses are undetectable in nasopharyngeal secretions from adenotonsillectomized children

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Martins, Ronaldo Braganca ; Rocha, Lucas Penna ; Prates, Mirela Moreira ; Gagliardi, Talita Bianca ; Biasoli, Balduino ; Leite, Marcelo Junqueira ; Buzatto, Guilherme ; Hyppolito, Miguel Angelo ; Aragon, Davi Casale ; Tamashiro, Edwin ; Pereira Valera, Fabiana Cardoso ; Arruda, Eurico ; Anselmo-Lima, Wilma Terezinha

• Document type: Journal article
• Source: PLoS One; v. 12, n. 3 MAR 17 2017.
• Web of Science Citations: 1

Abstract

Respiratory viruses are frequently detected in association with chronic tonsillar hypertrophy in the absence of symptoms of acute respiratory infection (ARI). The present analysis was done in follow-up to a previous clinical study done by this same group. Nasopharyngeal washes (NPWs) were obtained from 83 of 120 individuals at variable times post adenotonsillectomy, in the absence of ARI symptoms. A look back at virus detection results in NPWs from the same 83 individuals at the time of tonsillectomy revealed that 73.5% (61/83) were positive for one or more viruses. The overall frequency of respiratory virus detection in posttonsillectomy NPWs was 58.8%. Rhinovirus (RV) was the agent most frequently detected, in 38 of 83 subjects (45.8%), followed by enterovirus in 7 (8.4%), human metapneumovirus in 6 (7.2%), human respiratory syncytial virus in 3 (3.6%) and human coronavirus in 1 (1.2%). Remarkably, there was no detection of adenovirus (HAdV) or human bocavirus (HBoV) in asymptomatic individuals in follow-up of adenotonsillectomy. In keeping with persistence of respiratory DNA viruses in human tonsils, tonsillectomy significantly reduces asymptomatic shedding of HAdV and HBoV in NPWs. (AU)

• FAPESP's process: 13/16349-2 - Studies on persisting infections by human respiratory Paramyxoviruses
• Grantee: Eurico de Arruda Neto
• Support Opportunities: Regular Research Grants