Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Column switching UHPLC-MS/MS with restricted access material for the determination of CNS drugs in plasma samples

Full text
Author(s):
Acquaro Junior, Vinicius Ricardo ; Domingues, Diego Soares ; Costa Queiroz, Maria Eugenia
Total Authors: 3
Document type: Journal article
Source: BIOANALYSIS; v. 9, n. 6, p. 555-568, MAR 2017.
Web of Science Citations: 4
Abstract

Background: Polypharmacy is a common practice in schizophrenia. Consequently, therapeutic drug monitoring is usually adopted to maintain the concentrations of the drugs in the plasma within a targeted therapeutic range, to maximize therapeutic efficiency and to diminish adverse side effects. Methodology: This study reports on a column switching UHPLC-MS/MS method to determine psychotropic drugs in plasma samples simultaneously. Results: The method was linear from 0.025 to 1.25 ng ml(-1) with R-2 above 0.9950 and the lack of fit test (p > 0.05). The precision values presented coefficients of variation lower than 12%, and the relative standard error of the accuracy were lower than 14%. Conclusion: The column switching UHPLC-MS/MS method developed herein successfully determined drugs in schizophrenic patients' plasma samples for therapeutic drug monitoring. (AU)

FAPESP's process: 14/22140-1 - Two-dimensional Ultra-Efficiency Liquid Chromatography with Detection by Tandem Mass Spectrometry (2D-UPLC-MS/MS) for determination of drugs in plasma samples from schizophrenic patients
Grantee:Vinicius Ricardo Acquaro Junior
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/07619-1 - Column switching liquid chromatography coupled to tandem mass spectrometry for the analysis of endocannabinoids and drugs in biological samples
Grantee:Maria Eugênia Queiroz Nassur
Support type: Regular Research Grants