| Full text | |
| Author(s): |
Acquaro Junior, Vinicius Ricardo
;
Domingues, Diego Soares
;
Costa Queiroz, Maria Eugenia
Total Authors: 3
|
| Document type: | Journal article |
| Source: | BIOANALYSIS; v. 9, n. 6, p. 555-568, MAR 2017. |
| Web of Science Citations: | 4 |
| Abstract | |
Background: Polypharmacy is a common practice in schizophrenia. Consequently, therapeutic drug monitoring is usually adopted to maintain the concentrations of the drugs in the plasma within a targeted therapeutic range, to maximize therapeutic efficiency and to diminish adverse side effects. Methodology: This study reports on a column switching UHPLC-MS/MS method to determine psychotropic drugs in plasma samples simultaneously. Results: The method was linear from 0.025 to 1.25 ng ml(-1) with R-2 above 0.9950 and the lack of fit test (p > 0.05). The precision values presented coefficients of variation lower than 12%, and the relative standard error of the accuracy were lower than 14%. Conclusion: The column switching UHPLC-MS/MS method developed herein successfully determined drugs in schizophrenic patients' plasma samples for therapeutic drug monitoring. (AU) | |
| FAPESP's process: | 15/07619-1 - Column switching liquid chromatography coupled to tandem mass spectrometry for the analysis of endocannabinoids and drugs in biological samples |
| Grantee: | Maria Eugênia Queiroz Nassur |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/22140-1 - Two-dimensional Ultra-Efficiency Liquid Chromatography with Detection by Tandem Mass Spectrometry (2D-UPLC-MS/MS) for determination of drugs in plasma samples from schizophrenic patients |
| Grantee: | Vinicius Ricardo Acquaro Junior |
| Support Opportunities: | Scholarships in Brazil - Doctorate |