| Full text | |
| Author(s): |
Correia, Valquirio G.
;
Abreu, Juliana C.
;
Barata, Caio A. E.
;
Andrade, Leandro H.
Total Authors: 4
|
| Document type: | Journal article |
| Source: | ORGANIC LETTERS; v. 19, n. 5, p. 1060-1063, MAR 3 2017. |
| Web of Science Citations: | 17 |
| Abstract | |
A novel and highly efficient synthetic approach to pyrroloindolines has been developed. The process is based on tandem radical addition/cyclization with inexpensive iron catalyst. This method tolerates a wide range of N-methyl-N-arylacrylamides as well carbamoyl radicals, providing access to a variety of functionalized 3,3-disubstituted oxindoles, key intermediates for many bioactive pyrroloindolines such as (+/-)-esermethole, (+/-)-deoxyeseroline, and (+/-)-physovenol methyl ether. (AU) | |
| FAPESP's process: | 16/05633-0 - Vanadium haloperoxidase: searching for new sources and their application in continuous flow system aiming selective reactions |
| Grantee: | Juliana Caldeira Abreu |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 13/04540-0 - Enzymatic transformation of CO2 under continuous flow |
| Grantee: | Leandro Helgueira de Andrade |
| Support Opportunities: | Scholarships abroad - Research |
| FAPESP's process: | 14/22457-5 - Development of biocatalytic systems for oxidation and reduction reactions |
| Grantee: | Leandro Helgueira de Andrade |
| Support Opportunities: | Regular Research Grants |