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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Decoralin Analogs with Increased Resistance to Degradation and Lower Hemolytic Activity

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Author(s):
Torres, Marcelo D. T. ; Pedron, Cibele N. ; Araujo, Iris ; Silva, Jr., Pedro I. ; Silva, Fernanda D. ; Oliveira, Vani X.
Total Authors: 6
Document type: Journal article
Source: CHEMISTRYSELECT; v. 2, n. 1, p. 18-23, JAN 10 2017.
Web of Science Citations: 11
Abstract

Decoralin is an antimicrobial peptide with activity against microorganisms and pronounced hemolytic activity. Decoralin analogs have been proposed, and the results indicated that when isoleucine at position 6 was substituted by phenylalanine residue, the peptides exhibited increased resistance towards enzymes action. Besides that, lower hemolytic activity was obtained for {[}Pro](4)-Decoralin-NH2 and {[}Phe](6)-Des{[}Thr](11)-Decoralin-NH2; this effect is probably due to their poor helical tendency. {[}Arg](1)-Decoralin-NH2 exhibited + 4 net charge and lower hemolytic activity (25.0 mu mol L-1) and even showed helical propensity; as a consequence, it presented the higher therapeutic indexes (values from 16.0 to 32.0). The helical conformational tendency is believed to be determinant of the antimicrobial activity of this decoralin family and has been shown to be as important as the increased positive net charge. This points to a new direction for the design of potential chemotherapeutic agents. (AU)

FAPESP's process: 14/04507-5 - Biological applications of new antimicrobial peptides
Grantee:Marcelo Der Torossian Torres
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/12938-6 - Biologically active peptides against pathogenic micro-organisms
Grantee:Vani Xavier de Oliveira Junior
Support type: Regular Research Grants