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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pathogenesis of Vesicular Stomatitis New Jersey Virus Infection in Deer Mice (Peromyscus maniculatus) Transmitted by Black Flies (Simulium vittatum)

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Author(s):
Mesquita, L. P. ; Diaz, M. H. ; Howerth, E. W. ; Stallknecht, D. E. ; Noblet, R. ; Gray, E. W. ; Mead, D. G.
Total Authors: 7
Document type: Journal article
Source: VETERINARY PATHOLOGY; v. 54, n. 1, p. 74-81, JAN 2017.
Web of Science Citations: 2
Abstract

The natural transmission of vesicular stomatitis New Jersey virus (VSNJV), an arthropod-borne virus, is not completely understood. Rodents may have a role as reservoir or amplifying hosts. In this study, juvenile and nestling deer mice (Peromyscus maniculatus) were exposed to VSNJV-infected black fly (Simulium vittatum) bites followed by a second exposure to naive black flies on the nestling mice. Severe neurological signs were observed in some juvenile mice by 6 to 8 days postinoculation (DPI); viremia was not detected in 25 juvenile deer mice following exposure to VSNJV-infected fly bites. Both juvenile and nestling mice had lesions and viral antigen in the central nervous system (CNS); in juveniles, their distribution suggested that the sensory pathway was the most likely route to the CNS. In contrast, a hematogenous route was probably involved in nestling mice, since all of these mice developed viremia and had widespread antigen distribution in the CNS and other tissues on 2 DPI. VSNJV was recovered from naive flies that fed on viremic nestling mice. This is the first report of viremia in a potential natural host following infection with VSNJV via insect bite and conversely of an insect becoming infected with VSNJV by feeding on a viremic host. These results, along with histopathology and immunohistochemistry, show that nestling mice have widespread dissemination of VSNJV following VSNJV-infected black fly bite and are a potential reservoir or amplifying host for VSNJV. (AU)

FAPESP's process: 14/20631-8 - Chemokine responses in brain of deer mouse (Peromyscus maniculatus) experimentally infected with vesicular stomatitis virus
Grantee:Leonardo Pereira Mesquita
Support Opportunities: Scholarships abroad - Research Internship - Doctorate