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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Temporomandibular disorders and painful comorbidities: clinical association and underlying mechanisms

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Author(s):
Costa, Yuri Martins ; Rodrigues Conti, Paulo Cesar ; Cardoso de Faria, Flavio Augusto ; Bonjardim, Leonardo Rigoldi
Total Authors: 4
Document type: Journal article
Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 123, n. 3, p. 288-297, MAR 2017.
Web of Science Citations: 10
Abstract

The association between temporomandibular disorders (TMDs) and headaches, cervical spine dysfunction, and fibromyalgia is not artefactual. The aim of this review is to describe the comorbid relationship between TMD and these three major painful conditions and to discuss the clinical implications and the underlying pain mechanisms involved in these relationships. Common neuronal pathways and central sensitization processes are acknowledged as the main factors for the association between TMD and primary headaches, although the establishment of causeeeffect mechanisms requires further clarification and characterization. The biomechanical aspects are not the main factors involved in the comorbid relationship between TMD and cervical spine dysfunction, which can be better explained by the neuronal convergence of the trigeminal and cervical spine sensory pathways as well as by central sensitization processes. The association between TMD and fibromyalgia also has supporting evidence in the literature, and the proposed main mechanism underlying this relationship is the impairment of the descending pain inhibitory system. In this particular scenario, a causeeeffect relationship is more likely to occur in one direction, that is, fibromyalgia as a risk factor for TMD. Therefore, clinical awareness of the association between TMD and painful comorbidities and the support of multidisciplinary approaches are required to recognize these related conditions. (AU)

FAPESP's process: 15/09913-4 - The effect of cutaneous afferents in the mechanical somatosensory profile of masticatory myofascial pain.
Grantee:Yuri Martins Costa
Support Opportunities: Scholarships in Brazil - Post-Doctoral