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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Design of a novel electrospinning setup for the fabrication of biomimetic scaffolds for meniscus tissue engineering applications

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Author(s):
Stocco, T. D. ; Rodrigues, B. V. M. ; Marciano, F. R. ; Lobo, A. O.
Total Authors: 4
Document type: Journal article
Source: Materials Letters; v. 196, p. 221-224, JUN 1 2017.
Web of Science Citations: 15
Abstract

The tissue engineering field has provided great efforts towards the development of potential treatments for meniscal injuries. The success of these strategies are linked to the creation of scaffolds that are able to mimic the extracellular matrix architecture of the native meniscus. However, most conventional electrospinning setups can only produce either 2D aligned fibrous structures or 3D fibrous scaffolds with fibers randomly distributed. Herein, we designed a novel electrospinning setup, which consisted of two metallic devices as collectors: an external cylindrical hollow piece with a central pin and a mobile internal hollow cylinder. A feasible approach to create single-layer scaffolds with both circumferentially and radially aligned ultrathin fibers was developed. Then, this investigation demonstrated a great potential for the application of these scaffolds towards meniscus tissue engineering, once they are able to reproduce the orientation of the main collagen fibers present in the extracellular matrix of the knee meniscus. (C) 2017 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/17877-7 - Development of new polymeric scaffolds by electrospinning technique with incorporation of vertically aligned carbon nanotubes and nanohidroxyapatite for bone tissue regeneration
Grantee:Anderson de Oliveira Lobo
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 15/09697-0 - Electrospinning of novel functional nanobiomaterials based on peptides and bottlebrush polymers for tissue engineering
Grantee:Anderson de Oliveira Lobo
Support type: Scholarships abroad - Research
FAPESP's process: 11/20345-7 - Study of nanoparticle-incorporated diamond-like carbon films for biomedical applications
Grantee:Fernanda Roberta Marciano
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 15/08523-8 - Development of a fluorescent nanosensor from the electrospinning of PVA and graphene quantum dots: application in the detection of Alzheimer's biomarkers
Grantee:Bruno Vinícius Manzolli Rodrigues
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/00575-1 - Functional biomembranes based on peptides and bottlebrush polymers to tissue engineering
Grantee:Fernanda Roberta Marciano
Support type: Scholarships abroad - Research