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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vitro metabolism studies of natural products are crucial in the early development of medicines

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Moreira, Fernanda L. ; Marques, Lucas M. M. ; Lopes, Norberto P. ; de Oliveira, Anderson R. M.
Total Authors: 4
Document type: Review article
Source: PHYTOCHEMISTRY REVIEWS; v. 16, n. 2, p. 355-373, APR 2017.
Web of Science Citations: 2

Finding new drugs is imperative especially in the case of diseases such as serious infections and cancer, for which a gap in drug development exists. Plant-derived compounds display large structural diversity and constitute a source of novel medicinal agents. However, some drug candidates have failed in advanced stages of clinical and commercial use. In vitro tools have been effectively used to anticipate and to explore undesirable drug properties during early drug development. In this review, we address the purpose and advantages of conducting metabolic studies on natural products, and we describe how in vitro metabolism methods have contributed to delineating plant-based drug candidates. We also deal with the applications of in vitro metabolism studies on natural product-based drug development, which include characterization of the metabolites, investigation into enzymatic kinetics, prediction of drug clearance, phenotyping studies, and evaluation of natural product-drug interactions. (AU)

FAPESP's process: 14/50265-3 - Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation
Grantee:Norberto Peporine Lopes
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 13/16496-5 - In vitro, in vivo metabolism and pharmacokinetic profile evaluation of the alkaloid govaniadine
Grantee:Lucas Maciel Mauriz Marques
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/04188-4 - In vitro metabolism study and enzymatic inhibition of natural product piplartine employing human liver microsomes and supersomes.
Grantee:Fernanda de Lima Moreira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/07597-0 - Development of chromatographic/electrophoretic methods to be further used in in vitro enzymatic inhibition and drug interaction of chiral pesticides
Grantee:Anderson Rodrigo Moraes de Oliveira
Support type: Regular Research Grants