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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Determination of serum aflatoxin B-1-lysine to evaluate the efficacy of an aflatoxin-adsorbing feed additive in pigs fed an aflatoxin B-1-contaminated diet

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Author(s):
Di Gregorio, Mayra Carraro ; Jager, Alessandra Vincenzi ; Maggio Castro Souto, Pollyana Cristina ; Costa, Aline Alves ; Rottinghaus, George Edwin ; Passarelli, Danielle ; Lemos Budino, Fabio Enrique ; Corassin, Carlos Humberto ; Fernandes Oliveira, Carlos Augusto
Total Authors: 9
Document type: Journal article
Source: MYCOTOXIN RESEARCH; v. 33, n. 2, p. 93-102, MAY 2017.
Web of Science Citations: 2
Abstract

In this study, serum aflatoxin B-1 (AFB(1))-lysine was determined in order to evaluate the in vivo efficacy of a hydrated sodium calcium aluminosilicate (HSCAS) in pigs fed AFB(1). Twenty-four 49-day-old crossbred barrows were maintained in individual cages and allowed ad libitum access to feed and water. A completely randomized design was used with six animals assigned to each of four dietary treatments for 21 days as follows: (A) basal diet (BD), (B) BD supplemented with 0.5 % HSCAS, (C) BD supplemented with 1.1 mg/kg AFB(1), and (D) BD supplemented with 0.5 % HSCAS and 1.1 mg/kg AFB(1). HSCAS was able to alleviate the toxic effects of AFB(1) on pigs and reduce (P < 0.05) the levels of serum AFB(1)-lysine. Cumulative reductions of adduct yield values, calculated through the equation {[}(pg AFB(1)-lysine/mg albumin) / (mu g AFB(1)/kg body weight)], were 53.0, 62.8, and 72.1 after 7, 14, and 21 days of oral exposure, respectively. AFB(1)-lysine has potential as an AFB(1)-specific biomarker for diagnostic purposes and for evaluating the efficacy of chemoprotective interventions in pigs. (AU)

FAPESP's process: 12/12705-6 - Determination of aflatoxin B1 biomarkers and its applicability for evaluation of adsorbents efficiency in pigs
Grantee:Mayra Carraro Di Gregorio
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 10/20895-4 - Evaluation of AFB1-Lisin and AFB1-N7-guanin aducts as biomarkers of human and animal exposure to aflatoxins
Grantee:Carlos Augusto Fernandes de Oliveira
Support Opportunities: Research Projects - Thematic Grants