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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hormetic modulation of hepatic insulin sensitivity by advanced glycation end products

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Fabre, Nelly T. ; Thieme, Karina ; Silva, Karolline S. ; Catanozi, Sergio ; Cavaleiro, Ana Mercedes ; Pinto, Jr., Danilo A. C. ; Okamoto, Maristela M. ; Morais, Mychel Raony P. T. ; Falquetto, Barbara ; Zorn, Telma M. ; Machado, Ubiratan E. ; Passarelli, Marisa ; Correa-Giannella, Maria Lucia
Total Authors: 13
Document type: Journal article
Source: Molecular and Cellular Endocrinology; v. 447, n. C, p. 116-124, MAY 15 2017.
Web of Science Citations: 3
Abstract

Because of the paucity of information regarding metabolic effects of advanced glycation end products (AGEs) on liver, we evaluated effects of AGEs chronic administration in (1) insulin sensitivity; (2) hepatic expression of genes involved in AGEs, glucose and fat metabolism, oxidative stress and inflammation and; (3) hepatic morphology and glycogen content. Rats received intraperitoneally albumin modified (AIbAGE) or not by advanced glycation for 12 weeks. AIbAGE induced whole-body insulin resistance concomitantly with increased hepatic insulin sensitivity, evidenced by activation of AKT, inactivation of GSK3, increased hepatic glycogen content, and decreased expression of gluconeogenesis genes. Additionally there was reduction in hepatic fat content, in expression of lipogenic, pro-inflamatory and pro oxidative genes and increase in reactive oxygen species and in nuclear expression of NRF2, a transcription factor essential to cytoprotective response. Although considered toxic, AGEs become protective when administered chronically, stimulating AKT signaling, which is involved in cellular defense and insulin sensitivity. (C) 2017 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 14/17251-9 - The effects of chronic administration of albumin modified by advanced glycation (AGE) on renal tissue: characterization of the inflammatory, antioxidant and epigenetic profile
Grantee:Karina Thieme
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/04831-1 - New players in glycemic control and chronic complications of Diabetes mellitus: preventive and therapeutic perspectives
Grantee:Ubiratan Fabres Machado
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/18724-2 - Advanced glycated albumin and insulin resistance in rats: focus on periepididimal adipose tissue and N-acetylcysteine actions
Grantee:Karolline Santana da Silva
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/00713-7 - Effects of chronic administration of albumin modified by advanced glycation (age) on liver tissue: characterization of histological, inflammatory and antioxidant profile
Grantee:Nelly Takashima Fabre
Support type: Scholarships in Brazil - Master