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Relationship between time of fructose intake and hypothalamic AMPK rhythm: possible connections of the metabolic outcome with melatonin production

Grant number: 12/11409-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2012
Effective date (End): July 31, 2016
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Gabriel Forato Anhê
Grantee:Juliana de Almeida Faria
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):14/17012-4 - Uma intervenção Farmacológica para prevenir os efeitos da obesidade materna sobre a resistência à insulina no tecido adiposo da prole, BE.EP.DR


The consuption of fructose enriched diets exerts a well recognized effect on glucose homeostasis that is hallmarked by insulin resistance, hepatic steatosis and increased gluconeogesis. The precise mechanism underlying these effects are not completely known but a role for hypothalamic AMPK activation has been demonstrated in the onset of hyperphagia and upregulation of gluconeogenesis. Among several endocrine modulations, fructose was recently described to inhibit nocturnal surge of melatonin. Melatonin is a hormone produced in a circadian fashion that synchronizes the energetic metabolism by increasing insulin sensitivity and decreasing gluconeogenesis. As for melatonin production, AMPK activity varies throughout the light dark/cycle in a circadian fashion with peaking levels during the night. It was recently demonstrated that increasing hypothalamic AMPK activity reduces melatonin production. Interestingly, daytime ingested fructose worsens glucose homeostasis in more dramatic levels than nighttime ingested fructose. The present investigation intends to evaluate if the metabolic alterations induced by daytime ingested fructose are dependent on changes in AMPK rhythm and melatonin production.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FARIA, JULIANA DE ALMEIDA; DE ARAUJO, THIAGO MATOS F.; RAZOLLI, DANIELA S.; IGNACIO-SOUZA, LETICIA MARTINS; SOUZA, DAILSON NOGUEIRA; BORDIN, SILVANA; ANHE, GABRIEL FORATO. Metabolic Impact of Light Phase-Restricted Fructose Consumption Is Linked to Changes in Hypothalamic AMPK Phosphorylation and Melatonin Production in Rats. NUTRIENTS, v. 9, n. 4, . (12/11409-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FARIA, Juliana de Almeida. Light phase restricted fructose consumption and its implications on hypothalamic AMPK activation, melatonin production and glucose metabolism. 2016. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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