| Full text | |
| Author(s): |
Saad, Laura O.
;
do Rosario, Maria C.
;
Cesar, Raony C.
;
Batistuzzo, Marcelo C.
;
Hoexter, Marcelo Q.
;
Manfro, Gisele G.
;
Shavitt, Roseli G.
;
Leckman, James F.
;
Miguel, Euripedes C.
;
Alvarenga, Pedro G.
Total Authors: 10
|
| Document type: | Journal article |
| Source: | JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY; v. 27, n. 4, p. 342-348, MAY 2017. |
| Web of Science Citations: | 1 |
| Abstract | |
Objective: The aims of this study were (1) to assess obsessive-compulsive symptoms (OCS) dimensionally in a school-aged community sample and to correlate them with clinical and demographical variables; (2) to determine a subgroup with significant OCS ``at-risk for OCD'') using the Child Behavior Checklist (CBCL-OCS) and (3) to compare it with the rest of the sample; (4) To review the CBCL-OCS subscale properties as a screening tool for pediatric OCD. Methods: Data from the Brazilian High Risk Cohort were analyzed. The presence and severity of OCS were assessed through the CBCL-OCS subscale. DSM-IV psychiatric diagnoses were obtained by the Developmental and Well-Being Assessment. Behavioral problems were assessed using the Strengths and Difficulties Questionnaire, the Youth Strengths Inventory, and the CBCL internalizing and externalizing behavior subscales. Results: A total of 2512 (mean age: 8.86 +/- 1.84 years; 55.0% male) children were included. Moderate correlations were found between OCS severity and functional impairment (r = 0.36, p < 0.001). Children with higher levels of OCS had higher rates of psychiatric comorbidity and behavioral problems (p < 0.001). A score of 5 or higher in the CBCL-OCS scale determined an ``at-risk for OCD'' subgroup, comprising 9.7% of the sample (n = 244), with behavioral patterns and psychiatric comorbidities (e.g., tics {[}odds ratios, OR = 6.41, p < 0.001]), anxiety disorders grouped {[}OR = 3.68, p < 0.001] and depressive disorders {[}OR = 3.0, p < 0.001] very similar to those described in OCD. Sensitivity, specificity, positive predictive value, and negative predictive value of the CBCL-OCS for OCD diagnosis were, respectively, 48%, 91.5%; 15.1%, and 98.2%. Conclusions: The dimensional approach suggests that the presence of OCS in children is associated with higher rates of comorbidity, behavioral problems, and impairment. The ``at-risk for OCD'' group defined by the CBCL revealed a group of patients phenotypically similar to full blown OCD. (AU) | |
| FAPESP's process: | 08/57896-8 - National Institute for Developmental Psychiatry |
| Grantee: | Eurípedes Constantino Miguel Filho |
| Support Opportunities: | Research Projects - Thematic Grants |