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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Preconception allergen sensitization can induce B10 cells in offspring: a potential main role for maternal IgG

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Author(s):
de Oliveira, Marlia Garcia ; Oliveira, Luana de Mendonca ; de Lima Lira, Aline Aparecida ; Sgnotto, Fabio da Ressureicao ; da Silva Duarte, Alberto Jose ; Sato, Maria Notomi ; Victor, Jefferson Russo
Total Authors: 7
Document type: Journal article
Source: ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY; v. 13, APR 17 2017.
Web of Science Citations: 7
Abstract

Background: The mechanisms through which allergies can be inhibited after preconception immunization with allergens are not fully understood. We aimed to evaluate whether maternal immunization can induce a regulatory B (B10) cell population in offspring in concert with allergy inhibition. Methods: C57BL/6 females were or were not immunized with OVA and were mated with normal WT males. Their offspring were evaluated at 3 days of age or 20 days after neonatal immunization. Human peripheral B cells from atopic and non-atopic individuals were also evaluated. Results: Preconception OVA immunization induced B10 cells in offspring, and IL-10 production appeared to be critical for FcyRIIB upregulation in offspring B cells. Murine and human IL-10-producing B cells responded in vitro to IgG according to the atopic repertoire of the cells. Conclusions: Our results reveal that maternal immunization induces allergen-specific B10 cells in offspring and a pivotal role for the IgG repertoire in IL-10 production by murine and human B cells. (AU)

FAPESP's process: 15/17256-3 - "Mechanisms involved on offspring allergy development regulation by maternal immunization: role of cytokines, induction of T and B regulatory cells and allergen nature."
Grantee:Alberto José da Silva Duarte
Support Opportunities: Regular Research Grants
FAPESP's process: 13/22820-0 - Influence of maternal immunization with ovalbumin in thymic maturation of lymphocytes TCD4+, TCD8+, nTreg, T gamma delta and B on offspring
Grantee:Marília Garcia de Oliveira
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 10/09004-0 - Maternal immunization with Ovalbumin prevents allergy development in the offspring: evaluation of FcgammaRIIB receptors involvement and the role of regulatory cytokines and T cells.
Grantee:Jefferson Russo Victor
Support Opportunities: Scholarships in Brazil - Post-Doctoral